Patient course and outcome after allo- or syn-SCT
UPN allogeneic . | Year of allo-SCT . | Disease status at SCT . | Conditioning . | Ex vivo T-cell depletion . | Engraftment . | aGvHD/grade . | cGvHD . | Best hematologic remission to SCT . | Best organ response to SCT (evaluable organs) . | Observation, d . | Current status (cause of death) . |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Non-RIC | |||||||||||
| 26256341 | 1995 | NR | 10 Gy TBI/Cy | No | NE | No | NE | NE | NE | 28 | TRM (GI hemorrhage) |
| 23491761 | 1995 | Untreated | 8 Gy TBI/Mel | No | Yes | Yes/2 | Lim | CR | RESP (kidney) | 1253 | TRM (pneumonia) |
| 24006981 | 1997 | Untreated | 10 Gy TBI/Cy/Mel | Yes | Yes, lost graft at 6 mo | No | NE | PR | RESP (kidney, liver, PNP) | 2371 | PR |
| 16092762 | 2002 | Relapse | Bu/Cy/ATG | No | Yes | No | No | CR * | NE | 1016 | CR * |
| 7179454 | 1994 | PR | 12 Gy TBI/Mel | No | Yes | Yes/1 | Lim | CR | RESP (tongue) | 3633 | CR |
| 23924891 | 1998 | PR | 12 Gy TBI/Cy | Yes | Yes | Yes/3 | NE | CR | RESP (kidney) | 106 | TRM (EBV lymphoma) |
| 23925391 | 1999 | NR | 12 Gy TBI/Cy | Yes | Yes | Yes/4 | NE | NE | NE | 54 | TRM (cerebral aspergillosis) |
| RIC | |||||||||||
| 38906001 | 1998 | Untreated | 2 Gy TBI | No | Yes, lost graft at 2 mo | No | NE | NE | NE | 51 | TRM (cardiac death) |
| 25596342 | 2002 | Relapse | Flu/Mel/campath | No | Yes | No | NE | NE | NE | 83 | Death from AL amyloidosis (liver failure) |
| 1600237 | 2003 | PR | 2 Gy TBI/Flu/ATG | No | Yes | Yes/2 | Lim | CR | SD (heart) | 595 | Relapse |
| 81100832 | 2003 | PR | Flu/Mel/ATG | No | Yes | Yes/2 | Ext | PR | RESP (kidney) | 166 | TRM (cardiac death) |
| 23908912 | 2003 | Relapse | 2 Gy TBI/Flu/ATG | No | Yes | Yes/2 | Ext | CR | RESP (muscle) | 560 | CR |
| 1600231 | 2002 | PR | 2 Gy TBI/Flu | No | Yes | No | No | CR | RESP (muscle, tongue, kidney) | 853 | CR |
| 33998213 | 2002 | Relapse | Cy/Flu/ATG | No | Yes | No | Lim | CR | RESP (kidney) | 931 | CR |
| 77247721 | 2002 | Untreated | Mel | Yes | Yes | No | No | NR | RESP (heart) | 573 | Death from AL amyloidosis (cardiac death) |
| Syngeneic | |||||||||||
| 23923221 | 1991 | NR | 12 Gy TBI/Cy | No | Yes | NA | NA | CR | RESP (kidney, PNP) | 4667 | CR |
| 61402181 | 1997 | NA | Mel | No | Yes | NA | NA | CR | RESP (gut, PNP, joints) | 2902 | CR |
| 21405051 | 1997 | NR | Mel | No | NE | NA | NA | NE | NE | 7 | TRM (cardiac arrest, sepsis) |
| 26203731 | 2000 | PROG | Mel | No | NE | NA | NA | NE | NE | 18 | TRM (cardiac arrest, sepsis) |
UPN allogeneic . | Year of allo-SCT . | Disease status at SCT . | Conditioning . | Ex vivo T-cell depletion . | Engraftment . | aGvHD/grade . | cGvHD . | Best hematologic remission to SCT . | Best organ response to SCT (evaluable organs) . | Observation, d . | Current status (cause of death) . |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Non-RIC | |||||||||||
| 26256341 | 1995 | NR | 10 Gy TBI/Cy | No | NE | No | NE | NE | NE | 28 | TRM (GI hemorrhage) |
| 23491761 | 1995 | Untreated | 8 Gy TBI/Mel | No | Yes | Yes/2 | Lim | CR | RESP (kidney) | 1253 | TRM (pneumonia) |
| 24006981 | 1997 | Untreated | 10 Gy TBI/Cy/Mel | Yes | Yes, lost graft at 6 mo | No | NE | PR | RESP (kidney, liver, PNP) | 2371 | PR |
| 16092762 | 2002 | Relapse | Bu/Cy/ATG | No | Yes | No | No | CR * | NE | 1016 | CR * |
| 7179454 | 1994 | PR | 12 Gy TBI/Mel | No | Yes | Yes/1 | Lim | CR | RESP (tongue) | 3633 | CR |
| 23924891 | 1998 | PR | 12 Gy TBI/Cy | Yes | Yes | Yes/3 | NE | CR | RESP (kidney) | 106 | TRM (EBV lymphoma) |
| 23925391 | 1999 | NR | 12 Gy TBI/Cy | Yes | Yes | Yes/4 | NE | NE | NE | 54 | TRM (cerebral aspergillosis) |
| RIC | |||||||||||
| 38906001 | 1998 | Untreated | 2 Gy TBI | No | Yes, lost graft at 2 mo | No | NE | NE | NE | 51 | TRM (cardiac death) |
| 25596342 | 2002 | Relapse | Flu/Mel/campath | No | Yes | No | NE | NE | NE | 83 | Death from AL amyloidosis (liver failure) |
| 1600237 | 2003 | PR | 2 Gy TBI/Flu/ATG | No | Yes | Yes/2 | Lim | CR | SD (heart) | 595 | Relapse |
| 81100832 | 2003 | PR | Flu/Mel/ATG | No | Yes | Yes/2 | Ext | PR | RESP (kidney) | 166 | TRM (cardiac death) |
| 23908912 | 2003 | Relapse | 2 Gy TBI/Flu/ATG | No | Yes | Yes/2 | Ext | CR | RESP (muscle) | 560 | CR |
| 1600231 | 2002 | PR | 2 Gy TBI/Flu | No | Yes | No | No | CR | RESP (muscle, tongue, kidney) | 853 | CR |
| 33998213 | 2002 | Relapse | Cy/Flu/ATG | No | Yes | No | Lim | CR | RESP (kidney) | 931 | CR |
| 77247721 | 2002 | Untreated | Mel | Yes | Yes | No | No | NR | RESP (heart) | 573 | Death from AL amyloidosis (cardiac death) |
| Syngeneic | |||||||||||
| 23923221 | 1991 | NR | 12 Gy TBI/Cy | No | Yes | NA | NA | CR | RESP (kidney, PNP) | 4667 | CR |
| 61402181 | 1997 | NA | Mel | No | Yes | NA | NA | CR | RESP (gut, PNP, joints) | 2902 | CR |
| 21405051 | 1997 | NR | Mel | No | NE | NA | NA | NE | NE | 7 | TRM (cardiac arrest, sepsis) |
| 26203731 | 2000 | PROG | Mel | No | NE | NA | NA | NE | NE | 18 | TRM (cardiac arrest, sepsis) |
Non-RIC indicates non-reduced-intensity conditioning; NR, no response; TBI, total body irradiation; Cy, cyclophosphamide; NE, not evaluable; TRM, transplant-related mortality; Mel, melphalan; Lim, limited; CR, complete response; RESP, response; PR, partial response; NA, not available; Bu, busulphan; ATG, antithymocyte globulin; EBV, Epstein-Barr virus; Flu, fludarabine; AL, amyloid light-chain; SD, stable disease; Ext, extensive; and PROG, progression.
Immunofixation negative with persistent abnormal free light-chain ratio in the serum.