Ras/FGFR3 status, baseline PKC/c-FOS levels, and PKC412 IC50s for HMCLs
| . | U266 . | LP-1 . | RPMI-8226 . | OPM2 . | NCI-H929 . | KMS-11 . |
|---|---|---|---|---|---|---|
| PKC α | − | − | − | + | + | ND |
| PKC βI | + | + | + | + | + | ND |
| PKC βII | + | ++ | + | +/− | + | ND |
| PKC γ | − | − | − | − | + | ND |
| Activating FGFR3 mutation | − | − | − | + | − | + |
| Activating RAS mutation | − | − | + | − | + | − |
| Total PKC expression | +/− | ++ | + | +++ | +++ | +++ |
| Baseline C-FOS expression | ++ | +/− | +/− | +++ | ++ | +/− |
| PKC412 IC50, μM | 4.6 | 4.1 | 1 | 0.75 | 0.4 | 2.9 |
| . | U266 . | LP-1 . | RPMI-8226 . | OPM2 . | NCI-H929 . | KMS-11 . |
|---|---|---|---|---|---|---|
| PKC α | − | − | − | + | + | ND |
| PKC βI | + | + | + | + | + | ND |
| PKC βII | + | ++ | + | +/− | + | ND |
| PKC γ | − | − | − | − | + | ND |
| Activating FGFR3 mutation | − | − | − | + | − | + |
| Activating RAS mutation | − | − | + | − | + | − |
| Total PKC expression | +/− | ++ | + | +++ | +++ | +++ |
| Baseline C-FOS expression | ++ | +/− | +/− | +++ | ++ | +/− |
| PKC412 IC50, μM | 4.6 | 4.1 | 1 | 0.75 | 0.4 | 2.9 |
Basal PKC and c-fos expression reported as not detected (−), weakly detected (+/−), detected (+), strongly detected (++), very strongly detected (+++) by Western blot/RT-PCR. PKC412 IC50 was determined using MTS assay (Promega).
ND indicates not determined.