Effect of ara-C alone and in combination with UCN-01 on absolute blast counts during therapy
. | . | . | . | . | Absolute blast count/μL . | . | . | . | ||
|---|---|---|---|---|---|---|---|---|---|---|
| Patient . | Age, y . | First CR duration, mo . | CG . | No. of prior therapies . | Before Rx . | ara-C 24 h . | ara-C 48 h + 24 h UCN-01 . | Response . | ||
| 1 | 39 | 35 | t(8,21) | 1 | ND | 3 120 | ND | CR | ||
| 2 | 67 | 0 | dip | 1 | 46 787 | 10 512 | 700 | Resistant | ||
| 3 | 55 | 24 | dip | 2 | 15 210 | 11 620 | 1 890 | Resistant | ||
| 4 | 20 | 26 | t(8,21) | 2 | 28 644 | 11 340 | 2 407 | Resistant | ||
| 5 | 71 | 38 | −Y | 2 | 16 297 | 15 224 | 2 508 | Early death | ||
| 6 | 44 | 41 | −5/−7 | 3 | 79 806 | 44 526 | 10 614 | Resistant | ||
| 7 | 51 | 0 | −5/−7 | 2 | 48 640 | 11 800 | 5 353 | Resistant | ||
| 8 | 67 | 11 | 11Q | 1 | 39 146 | 21 910 | 5 640 | Resistant | ||
| 9 | 31 | 32 | MISC | 7 | 142 560 | 124 354 | 54 880 | Resistant | ||
| 10 | 41 | 65 | MISC | 5 | 13 104 | 7 268 | 2 046 | Resistant | ||
| 11 | 18 | 28 | MISC | 1 | 5 865 | 4 200 | 1 900 | Resistant | ||
| 12 | 38 | 5 | MISC | 4 | 10 586 | 11 480 | 1 040 | Resistant | ||
| 13 | 51 | 17 | −5/−7 | 1 | 39 476 | 31 947 | 3 510 | Early death | ||
. | . | . | . | . | Absolute blast count/μL . | . | . | . | ||
|---|---|---|---|---|---|---|---|---|---|---|
| Patient . | Age, y . | First CR duration, mo . | CG . | No. of prior therapies . | Before Rx . | ara-C 24 h . | ara-C 48 h + 24 h UCN-01 . | Response . | ||
| 1 | 39 | 35 | t(8,21) | 1 | ND | 3 120 | ND | CR | ||
| 2 | 67 | 0 | dip | 1 | 46 787 | 10 512 | 700 | Resistant | ||
| 3 | 55 | 24 | dip | 2 | 15 210 | 11 620 | 1 890 | Resistant | ||
| 4 | 20 | 26 | t(8,21) | 2 | 28 644 | 11 340 | 2 407 | Resistant | ||
| 5 | 71 | 38 | −Y | 2 | 16 297 | 15 224 | 2 508 | Early death | ||
| 6 | 44 | 41 | −5/−7 | 3 | 79 806 | 44 526 | 10 614 | Resistant | ||
| 7 | 51 | 0 | −5/−7 | 2 | 48 640 | 11 800 | 5 353 | Resistant | ||
| 8 | 67 | 11 | 11Q | 1 | 39 146 | 21 910 | 5 640 | Resistant | ||
| 9 | 31 | 32 | MISC | 7 | 142 560 | 124 354 | 54 880 | Resistant | ||
| 10 | 41 | 65 | MISC | 5 | 13 104 | 7 268 | 2 046 | Resistant | ||
| 11 | 18 | 28 | MISC | 1 | 5 865 | 4 200 | 1 900 | Resistant | ||
| 12 | 38 | 5 | MISC | 4 | 10 586 | 11 480 | 1 040 | Resistant | ||
| 13 | 51 | 17 | −5/−7 | 1 | 39 476 | 31 947 | 3 510 | Early death | ||
CR indicates complete remission; CG, cytogenetics; Rx, treatment; ND, not done; dip, diploid; and MISC, miscellaneous.