Description of study subjects by sex, age, and cytogenetic abnormality
| . | Medical Research Council (MRC) trials . | Leukaemia Research (LRF) studies . | Total* . | |||
|---|---|---|---|---|---|---|
| AML 10 . | AML 11 . | AML 12 . | AML . | Therapy AML . | ||
| Total, no. (%) | 30 | 321 | 207 | 343 | 66 | 927 |
| Sex, no. (%) | ||||||
| Male | 16 (53.3) | 182 (56.7) | 120 (58.0) | 188 (54.8) | 28 (42.4) | 512 (55.2) |
| Female | 14 (46.7) | 139 (43.3) | 87 (42.0) | 155 (45.2) | 38 (57.6) | 415 (44.8) |
| Age | ||||||
| Mean, y (standard deviation) | 41.4 (11.6) | 66.8 (5.5) | 41.0 (12.1) | 47.3 (14.5) | 55.1 (13.1) | 52.4 (15.6) |
| 16 to 39 y, no. (%) | 9 (30.0) | 0 | 88 (42.5) | 108 (31.5) | 11 (16.7) | 213 (23.0) |
| 40 to 59 y, no. (%) | 21 (70.0) | 36 (11.2) | 117 (56.5) | 150 (43.7) | 27 (40.9) | 338 (36.5) |
| 60 y or older, no. (%) | 0 | 285 (88.8) | 2 (1.0) | 85 (24.8) | 28 (42.4) | 376 (40.6) |
| Cytogenetic abnormalities, no. (%)† | ||||||
| Normal | 0 | 140 (26.9) | 73 (23.2) | 146 (30.4) | 20 (16.4) | 363 (25.1) |
| Monosomy | ||||||
| −5 | 3 (4.0) | 20 (3.9) | 10 (3.2) | 7 (1.5) | 4 (3.3) | 42 (2.9) |
| −7 | 9 (11.8) | 35 (6.7) | 12 (3.8) | 15 (3.1) | 12 (9.8) | 78 (5.4) |
| Trisomy | ||||||
| +8 | 3 (4.0) | 36 (6.9) | 17 (5.4) | 38 (7.9) | 10 (8.2) | 100 (6.9) |
| +21 | 2 (2.6) | 6 (1.2) | 5 (1.6) | 9 (1.9) | 1 (0.8) | 22 (1.5) |
| +22 | 1 (1.3) | 4 (0.8) | 4 (1.3) | 3 (0.6) | 1 (0.8) | 13 (0.9) |
| Translocation | ||||||
| t(15;17) | 1 (1.3) | 11 (2.1) | 33 (10.5) | 42 (8.3) | 8 (6.6) | 90 (6.2) |
| t(8;21) | 1 (1.3) | 6 (1.2) | 16 (5.1) | 24 (5.0) | 0 | 47 (3.3) |
| Deletion | ||||||
| del(5q) | 10 (13.2) | 39 (7.5) | 11 (3.5) | 7 (1.5) | 4 (3.3) | 69 (4.8) |
| del(7q) | 6 (7.9) | 17 (3.3) | 12 (3.8) | 15 (3.1) | 4 (3.3) | 47 (3.3) |
| del(9q) | 1 (1.3) | 8 (1.5) | 7 (2.2) | 6 (1.3) | 1 (0.8) | 22 (1.5) |
| Other | ||||||
| 3q | 0 | 10 (1.9) | 11 (3.5) | 9 (1.9) | 5 (4.1) | 39 (2.7) |
| 11q23 | 7 (9.2) | 8 (1.5) | 9 (2.9) | 14 (2.9) | 8 (6.6) | 41 (2.8) |
| Inversion(16) | 1 (1.3) | 4 (0.8) | 7 (2.2) | 14 (2.9) | 1 (0.8) | 26 (1.8) |
| Complex‡ | 8 (10.5) | 49 (9.4) | 25 (7.9) | 24 (5.0) | 12 (9.8) | 112 (7.8) |
| Any other abnormality | 18 (23.7) | 126 (24.3) | 63 (20.0) | 113 (23.5) | 31 (25.4) | 333 (23.0) |
| . | Medical Research Council (MRC) trials . | Leukaemia Research (LRF) studies . | Total* . | |||
|---|---|---|---|---|---|---|
| AML 10 . | AML 11 . | AML 12 . | AML . | Therapy AML . | ||
| Total, no. (%) | 30 | 321 | 207 | 343 | 66 | 927 |
| Sex, no. (%) | ||||||
| Male | 16 (53.3) | 182 (56.7) | 120 (58.0) | 188 (54.8) | 28 (42.4) | 512 (55.2) |
| Female | 14 (46.7) | 139 (43.3) | 87 (42.0) | 155 (45.2) | 38 (57.6) | 415 (44.8) |
| Age | ||||||
| Mean, y (standard deviation) | 41.4 (11.6) | 66.8 (5.5) | 41.0 (12.1) | 47.3 (14.5) | 55.1 (13.1) | 52.4 (15.6) |
| 16 to 39 y, no. (%) | 9 (30.0) | 0 | 88 (42.5) | 108 (31.5) | 11 (16.7) | 213 (23.0) |
| 40 to 59 y, no. (%) | 21 (70.0) | 36 (11.2) | 117 (56.5) | 150 (43.7) | 27 (40.9) | 338 (36.5) |
| 60 y or older, no. (%) | 0 | 285 (88.8) | 2 (1.0) | 85 (24.8) | 28 (42.4) | 376 (40.6) |
| Cytogenetic abnormalities, no. (%)† | ||||||
| Normal | 0 | 140 (26.9) | 73 (23.2) | 146 (30.4) | 20 (16.4) | 363 (25.1) |
| Monosomy | ||||||
| −5 | 3 (4.0) | 20 (3.9) | 10 (3.2) | 7 (1.5) | 4 (3.3) | 42 (2.9) |
| −7 | 9 (11.8) | 35 (6.7) | 12 (3.8) | 15 (3.1) | 12 (9.8) | 78 (5.4) |
| Trisomy | ||||||
| +8 | 3 (4.0) | 36 (6.9) | 17 (5.4) | 38 (7.9) | 10 (8.2) | 100 (6.9) |
| +21 | 2 (2.6) | 6 (1.2) | 5 (1.6) | 9 (1.9) | 1 (0.8) | 22 (1.5) |
| +22 | 1 (1.3) | 4 (0.8) | 4 (1.3) | 3 (0.6) | 1 (0.8) | 13 (0.9) |
| Translocation | ||||||
| t(15;17) | 1 (1.3) | 11 (2.1) | 33 (10.5) | 42 (8.3) | 8 (6.6) | 90 (6.2) |
| t(8;21) | 1 (1.3) | 6 (1.2) | 16 (5.1) | 24 (5.0) | 0 | 47 (3.3) |
| Deletion | ||||||
| del(5q) | 10 (13.2) | 39 (7.5) | 11 (3.5) | 7 (1.5) | 4 (3.3) | 69 (4.8) |
| del(7q) | 6 (7.9) | 17 (3.3) | 12 (3.8) | 15 (3.1) | 4 (3.3) | 47 (3.3) |
| del(9q) | 1 (1.3) | 8 (1.5) | 7 (2.2) | 6 (1.3) | 1 (0.8) | 22 (1.5) |
| Other | ||||||
| 3q | 0 | 10 (1.9) | 11 (3.5) | 9 (1.9) | 5 (4.1) | 39 (2.7) |
| 11q23 | 7 (9.2) | 8 (1.5) | 9 (2.9) | 14 (2.9) | 8 (6.6) | 41 (2.8) |
| Inversion(16) | 1 (1.3) | 4 (0.8) | 7 (2.2) | 14 (2.9) | 1 (0.8) | 26 (1.8) |
| Complex‡ | 8 (10.5) | 49 (9.4) | 25 (7.9) | 24 (5.0) | 12 (9.8) | 112 (7.8) |
| Any other abnormality | 18 (23.7) | 126 (24.3) | 63 (20.0) | 113 (23.5) | 31 (25.4) | 333 (23.0) |