Oligonucleotide microarray studies to examine the expression of various genes involved in the Wnt canonical pathway in 3 MCL cell lines and 3 primary tumors
| Gene name . | Mino . | Jeko-1 . | SP53 . | MCL-tumor 1 . | MCL-tumor 2 . | MCL-tumor 3 . | Median CT . |
|---|---|---|---|---|---|---|---|
| WNT3 | 23.92 | 23.73 | 22.78 | 23.73 | 20.92 | 20.95 | 23.26 |
| WNT10A | 21.61 | 23.84 | 24.87 | 25.42 | 20.62 | 24.43 | 24.15 |
| WNT16 | 25.28 | 24.86 | 28.00 | 24.21 | 24.97 | 27.87 | 25.14 |
| WNT5B | 25.31 | 27.79 | 27.70 | 29.65 | 23.61 | 28.59 | 27.75 |
| WNT8A | ND | 29.31 | 29.58 | 29.26 | 28.32 | 29.24 | 29.29 |
| WNT3A | 30.44 | 28.44 | 30.15 | 28.49 | 28.98 | 30.20 | 29.57 |
| WNT9A | ND | 27.82 | 37.36 | 29.79 | 27.22 | 29.74 | 29.77 |
| WNT5A | 31.67 | 26.34 | 34.82 | 31.30 | 29.67 | 28.37 | 30.49 |
| WNT2 | 30.57 | 30.56 | 33.00 | 33.36 | 28.32 | 31.52 | 31.05 |
| WNT7B | 33.62 | 30.65 | 29.77 | 31.43 | 29.22 | 31.54 | 31.04 |
| WNT11 | 36.95 | 28.85 | 31.16 | 29.92 | 32.27 | 31.98 | 31.57 |
| WNT4 | 33.92 | 29.84 | 31.35 | 32.80 | ND | 32.31 | 32.56 |
| WNT1 | 36.23 | 32.38 | 33.56 | 34.38 | 33.64 | 36.44 | 34.01 |
| WNT6 | 31.56 | 32.63 | 35.50 | 37.10 | 32.33 | 36.32 | 34.07 |
| WNT2B | ND | ND | 33.80 | 29.70 | 29.38 | 28.90 | 31.75 |
| WNT7A | ND | ND | ND | 32.39 | ND | 31.65 | ND |
| FZD3 | 20.86 | 22.58 | 22.85 | 27.21 | 22.23 | 23.92 | 22.72 |
| FZD2 | 21.95 | 24.61 | 23.44 | 27.23 | 26.20 | 24.96 | 24.79 |
| FZD6 | 21.54 | 27.21 | 24.71 | 25.63 | 22.92 | 25.54 | 25.13 |
| FZD7 | 25.22 | 24.14 | 26.25 | 25.43 | 25.00 | 25.44 | 25.33 |
| FZD8 | 29.00 | 28.77 | 27.53 | 27.27 | 27.57 | 27.32 | 27.55 |
| FZD4 | 32.21 | 31.23 | 29.70 | 26.46 | 24.39 | 27.14 | 28.42 |
| FZD1 | 33.27 | 34.77 | 35.34 | 34.95 | 37.10 | 34.51 | 34.86 |
| LRP5 | 21.16 | 22.49 | 23.39 | 24.68 | 26.28 | 24.53 | 23.96 |
| LEF1 | 19.92 | 21.81 | 24.59 | 24.78 | 19.85 | 24.3 | 25.54 |
| TCF7 | 26.38 | 27.46 | 28.31 | 28.28 | 26.54 | 27.69 | 27.44 |
| CCND1 | 18.86 | 20.61 | 18.93 | 22.54 | 25.25 | 22.18 | 21.40 |
| Gene name . | Mino . | Jeko-1 . | SP53 . | MCL-tumor 1 . | MCL-tumor 2 . | MCL-tumor 3 . | Median CT . |
|---|---|---|---|---|---|---|---|
| WNT3 | 23.92 | 23.73 | 22.78 | 23.73 | 20.92 | 20.95 | 23.26 |
| WNT10A | 21.61 | 23.84 | 24.87 | 25.42 | 20.62 | 24.43 | 24.15 |
| WNT16 | 25.28 | 24.86 | 28.00 | 24.21 | 24.97 | 27.87 | 25.14 |
| WNT5B | 25.31 | 27.79 | 27.70 | 29.65 | 23.61 | 28.59 | 27.75 |
| WNT8A | ND | 29.31 | 29.58 | 29.26 | 28.32 | 29.24 | 29.29 |
| WNT3A | 30.44 | 28.44 | 30.15 | 28.49 | 28.98 | 30.20 | 29.57 |
| WNT9A | ND | 27.82 | 37.36 | 29.79 | 27.22 | 29.74 | 29.77 |
| WNT5A | 31.67 | 26.34 | 34.82 | 31.30 | 29.67 | 28.37 | 30.49 |
| WNT2 | 30.57 | 30.56 | 33.00 | 33.36 | 28.32 | 31.52 | 31.05 |
| WNT7B | 33.62 | 30.65 | 29.77 | 31.43 | 29.22 | 31.54 | 31.04 |
| WNT11 | 36.95 | 28.85 | 31.16 | 29.92 | 32.27 | 31.98 | 31.57 |
| WNT4 | 33.92 | 29.84 | 31.35 | 32.80 | ND | 32.31 | 32.56 |
| WNT1 | 36.23 | 32.38 | 33.56 | 34.38 | 33.64 | 36.44 | 34.01 |
| WNT6 | 31.56 | 32.63 | 35.50 | 37.10 | 32.33 | 36.32 | 34.07 |
| WNT2B | ND | ND | 33.80 | 29.70 | 29.38 | 28.90 | 31.75 |
| WNT7A | ND | ND | ND | 32.39 | ND | 31.65 | ND |
| FZD3 | 20.86 | 22.58 | 22.85 | 27.21 | 22.23 | 23.92 | 22.72 |
| FZD2 | 21.95 | 24.61 | 23.44 | 27.23 | 26.20 | 24.96 | 24.79 |
| FZD6 | 21.54 | 27.21 | 24.71 | 25.63 | 22.92 | 25.54 | 25.13 |
| FZD7 | 25.22 | 24.14 | 26.25 | 25.43 | 25.00 | 25.44 | 25.33 |
| FZD8 | 29.00 | 28.77 | 27.53 | 27.27 | 27.57 | 27.32 | 27.55 |
| FZD4 | 32.21 | 31.23 | 29.70 | 26.46 | 24.39 | 27.14 | 28.42 |
| FZD1 | 33.27 | 34.77 | 35.34 | 34.95 | 37.10 | 34.51 | 34.86 |
| LRP5 | 21.16 | 22.49 | 23.39 | 24.68 | 26.28 | 24.53 | 23.96 |
| LEF1 | 19.92 | 21.81 | 24.59 | 24.78 | 19.85 | 24.3 | 25.54 |
| TCF7 | 26.38 | 27.46 | 28.31 | 28.28 | 26.54 | 27.69 | 27.44 |
| CCND1 | 18.86 | 20.61 | 18.93 | 22.54 | 25.25 | 22.18 | 21.40 |
Data are expressed in CT values normalized against GAPDH.
ND indicates not detectable.