Inhibition of IL-12p70 by STA-5326
| Cell type . | Stimulus . | Baseline value, pg/mL . | IC50, nM . |
|---|---|---|---|
| Human PBMCs | IFN-γ/SAC | 200 | 1 |
| Human PBMCs | IFN-γ/LPS | 180 | 10 |
| Human PBMCs | SAC | 5 | 5 |
| Human monocytes | IFN-γ/SAC | 180 | 1 |
| Human dendritic cells | IFN-γ/SAC | 130 | 5 |
| Human THP-1 | IFN-γ/SAC | 60 | 10 |
| Mouse PBMCs | IFN-γ/SAC | 30 | 2 |
| Mouse spleen cells/PBMCs | IFN-γ/SAC | 250 | 20 |
| Cell type . | Stimulus . | Baseline value, pg/mL . | IC50, nM . |
|---|---|---|---|
| Human PBMCs | IFN-γ/SAC | 200 | 1 |
| Human PBMCs | IFN-γ/LPS | 180 | 10 |
| Human PBMCs | SAC | 5 | 5 |
| Human monocytes | IFN-γ/SAC | 180 | 1 |
| Human dendritic cells | IFN-γ/SAC | 130 | 5 |
| Human THP-1 | IFN-γ/SAC | 60 | 10 |
| Mouse PBMCs | IFN-γ/SAC | 30 | 2 |
| Mouse spleen cells/PBMCs | IFN-γ/SAC | 250 | 20 |
All IC50s shown in the table are representatives of at least 3 studies.