Cytokine inhibitory spectrum of STA-5326
| Cell type . | Stimulus . | Cytokine . | Baseline value, pg/mL . | IC50, nM . |
|---|---|---|---|---|
| Human PBMCs | IFN-γ/SAC | IL-12 p70 | 200 | 1 |
| Human PBMCs | IFN-γ/SAC | IL-23 | 1 000 | 10 |
| Human PBMCs | IFN-γ/SAC | IL-12/IL-23 p40 | 6 000 | 20 |
| Human PBMCs | IFN-γ/SAC | IFN-γ | 28 000* | 20 |
| Human PBMCs | IFN-γ/SAC | IL-6 | 25 000 | 100 |
| Human PBMCs | IFN-γ/SAC | IL-10 | 2 000 | 200 |
| Human PBMCs | IFN-γ/SAC | TNF-α | 56 000 | 1000 |
| Human PBMCs | IFN-γ/SAC | IL-1β | 25 000 | > 1000 |
| Human PBMCs | IFN-γ/SAC | IL-8 | 1 000 | > 1000 |
| Human PBMCs | IFN-γ/SAC | IL-18 | 300 | > 1000 |
| Human PBMCs | IFN-γ/LPS | IL-12 p70 | 180 | 10 |
| Human PBMCs | IFN-γ/LPS | IL-6 | 32 000 | > 1000 |
| Human PBMCs | IFN-γ/LPS | IL-10 | 2 000 | > 1000 |
| Human PBMCs | ConA | IL-5 | 100 | 100 |
| Human PBMCs | ConA | IL-4 | 20 | > 1000 |
| Human PBMCs | αCD3/ αCD28 Ab | IFN-γ | 200 | > 1000 |
| Human PBMCs | αCD3/ αCD28 Ab | IL-4 | 40 | > 1000 |
| Human PBMCs | αCD3/ αCD28 Ab | IL-2 | 800 | > 1000 |
| Human THP-1 | IFN-γ/SAC | IL-12 p70 | 60 | 10 |
| Human THP-1 | IFN-γ/SAC | IL-6 | 9 000 | > 1000 |
| Cell type . | Stimulus . | Cytokine . | Baseline value, pg/mL . | IC50, nM . |
|---|---|---|---|---|
| Human PBMCs | IFN-γ/SAC | IL-12 p70 | 200 | 1 |
| Human PBMCs | IFN-γ/SAC | IL-23 | 1 000 | 10 |
| Human PBMCs | IFN-γ/SAC | IL-12/IL-23 p40 | 6 000 | 20 |
| Human PBMCs | IFN-γ/SAC | IFN-γ | 28 000* | 20 |
| Human PBMCs | IFN-γ/SAC | IL-6 | 25 000 | 100 |
| Human PBMCs | IFN-γ/SAC | IL-10 | 2 000 | 200 |
| Human PBMCs | IFN-γ/SAC | TNF-α | 56 000 | 1000 |
| Human PBMCs | IFN-γ/SAC | IL-1β | 25 000 | > 1000 |
| Human PBMCs | IFN-γ/SAC | IL-8 | 1 000 | > 1000 |
| Human PBMCs | IFN-γ/SAC | IL-18 | 300 | > 1000 |
| Human PBMCs | IFN-γ/LPS | IL-12 p70 | 180 | 10 |
| Human PBMCs | IFN-γ/LPS | IL-6 | 32 000 | > 1000 |
| Human PBMCs | IFN-γ/LPS | IL-10 | 2 000 | > 1000 |
| Human PBMCs | ConA | IL-5 | 100 | 100 |
| Human PBMCs | ConA | IL-4 | 20 | > 1000 |
| Human PBMCs | αCD3/ αCD28 Ab | IFN-γ | 200 | > 1000 |
| Human PBMCs | αCD3/ αCD28 Ab | IL-4 | 40 | > 1000 |
| Human PBMCs | αCD3/ αCD28 Ab | IL-2 | 800 | > 1000 |
| Human THP-1 | IFN-γ/SAC | IL-12 p70 | 60 | 10 |
| Human THP-1 | IFN-γ/SAC | IL-6 | 9 000 | > 1000 |
All IC50s shown in the table are representatives of at least 3 studies.
After subtraction of IFN-γ added as stimulus.