Table 3

Functional gene clusters overrepresented

Z scoreP% of selection% of all
Functional gene clusters overrepresented among up-regulated genes     
    Molecular function     
        Receptor activity 2.91 .013 19.5 10.2 
        Interleukin-1 receptor activity 11.76 <.001 3.4 0.1 
    Biological process     
        Immune response 5.71 <.001 20.7 6.1 
        Innate immune response 5.42 <.001 9.2 1.7 
        Chemotaxis 2.48 .04 3.4 0.9 
        Cell communication 2.39 .015 35.6 24.6 
        Intracellular signaling cascade 2.41 .018 13.8 7.2 
        MAPKKK cascade 3.99 .006 3.4 0.5 
        G-protein signaling, coupled to cAMP nucleotide second messenger 3.59 .009 3.4 0.6 
        Negative regulation of cell proliferation 2.95 .016 4.6 1.2 
        Cell activation 3.22 .03 3.4 0.7 
        Lymphocyte activation 3.64 .017 3.4 0.6 
        Cell motility 2.29 .026 6.9 2.8 
        Anti-inflammation/immunosuppression * 7.28 <.001 6.7 0.74 
        Phagocytosis* 5.21 <.001 5 0.69 
Functional gene clusters overrepresented among down-regulated genes     
    Molecular function     
        Receptor activity 2.42 .022 21.4 10.2 
        Chemokine activity 11.63 <.001 11.9 0.4 
    Biological process     
        Immune response 11.27 <.001 47.6 6.1 
        Humoral immune response 3.02 .031 7.1 1.5 
        Innate immune response 7.51 <.001 16.7 1.7 
        Negative regulation of cell proliferation 3.57 .013 7.1 1.2 
        Cell communication 2.75 .011 42.9 24.6 
        Cell-cell signaling 3.63 .005 16.7 4.8 
        Cell adhesion 2.88 .011 14.3 4.8 
        Signal transduction 2.66 .014 35.7 19.5 
        Apoptosis 2.98 .015 11.9 3.5 
        Cell motility 2.61 .034 9.5 2.8 
    Oxidative* 3.18 .004 13.3 4.0 
    IFNγ induced* 13.04 <.001 15.5 0.6 
    Phagocytosis* 4.87 <.001 6.7 0.69 
Z scoreP% of selection% of all
Functional gene clusters overrepresented among up-regulated genes     
    Molecular function     
        Receptor activity 2.91 .013 19.5 10.2 
        Interleukin-1 receptor activity 11.76 <.001 3.4 0.1 
    Biological process     
        Immune response 5.71 <.001 20.7 6.1 
        Innate immune response 5.42 <.001 9.2 1.7 
        Chemotaxis 2.48 .04 3.4 0.9 
        Cell communication 2.39 .015 35.6 24.6 
        Intracellular signaling cascade 2.41 .018 13.8 7.2 
        MAPKKK cascade 3.99 .006 3.4 0.5 
        G-protein signaling, coupled to cAMP nucleotide second messenger 3.59 .009 3.4 0.6 
        Negative regulation of cell proliferation 2.95 .016 4.6 1.2 
        Cell activation 3.22 .03 3.4 0.7 
        Lymphocyte activation 3.64 .017 3.4 0.6 
        Cell motility 2.29 .026 6.9 2.8 
        Anti-inflammation/immunosuppression * 7.28 <.001 6.7 0.74 
        Phagocytosis* 5.21 <.001 5 0.69 
Functional gene clusters overrepresented among down-regulated genes     
    Molecular function     
        Receptor activity 2.42 .022 21.4 10.2 
        Chemokine activity 11.63 <.001 11.9 0.4 
    Biological process     
        Immune response 11.27 <.001 47.6 6.1 
        Humoral immune response 3.02 .031 7.1 1.5 
        Innate immune response 7.51 <.001 16.7 1.7 
        Negative regulation of cell proliferation 3.57 .013 7.1 1.2 
        Cell communication 2.75 .011 42.9 24.6 
        Cell-cell signaling 3.63 .005 16.7 4.8 
        Cell adhesion 2.88 .011 14.3 4.8 
        Signal transduction 2.66 .014 35.7 19.5 
        Apoptosis 2.98 .015 11.9 3.5 
        Cell motility 2.61 .034 9.5 2.8 
    Oxidative* 3.18 .004 13.3 4.0 
    IFNγ induced* 13.04 <.001 15.5 0.6 
    Phagocytosis* 4.87 <.001 6.7 0.69 
*

Additional functional clusters identified by literature database search.

View Large
This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal