Gene expression analysis in cell lines by RT-PCR
| . | HOP . | HOXB9 . | HLXB9 . | HOXB4* . | mir-196a1 . |
|---|---|---|---|---|---|
| HL | |||||
| HD-70 | NE† | +† | NE† | +† | NE† |
| HDLM-2 | +† | +† | +† | +† | +† |
| KM-H2 | +† | +† | +† | ++† | +† |
| L-1236 | –† | +† | +† | ++† | +† |
| L-428 | –† | +† | +† | ++† | +† |
| L-540 | +† | +† | –† | +† | +† |
| SUP-HD1 | +† | +† | +† | ++† | +† |
| ALCL | |||||
| DEL | – | –† | +† | +† | NE† |
| FE-PD | NE | +† | –† | NE† | NE† |
| KARPAS-299 | – | +† | –† | +† | +† |
| JB6 | – | –† | +† | +† | NE† |
| KI-JK | – | –† | +† | +† | NE† |
| MAC2A | – | +† | +† | +† | NE† |
| SR-786 | – | –† | +† | +† | +† |
| SU-DHLI | NE | +† | NE† | NE† | NE† |
| SUP-M2 | + | +† | +† | ++† | +† |
| MLBCL | |||||
| KARPAS-1106P | NE | +† | –† | +† | NE |
| MedB-1 | – | +† | +† | +† | NE |
| DLCL/FL | |||||
| DB | – | – | +† | – | NE |
| DOHH2 | – | – | +† | – | NE |
| KARPAS-422 | – | – | +† | + | – |
| KIS-1 | NE | – | –† | + | – |
| OCI-LY-19 | NE | – | +† | NE | NE |
| RC-K8 | – | + | +† | – | + |
| RI-1 | – | – | +† | – | – |
| SBH-1 | – | – | +† | NE | NE |
| SC-1 | – | – | +† | – | – |
| SU-DHL-4 | – | – | –† | – | NE |
| WSU-NHL | – | – | –† | – | NE |
| MCL | |||||
| GRANTA-519 | NE | + | – | +† | NE |
| JEKO-1 | – | – | – | +† | NE |
| BL | |||||
| BL-41 | – | – | – | +† | – |
| BL-70 | – | – | – | –† | – |
| DAUDI | – | – | – | ++† | – |
| DG-75 | NE | – | – | NE† | NE |
| NAMALWA | – | + | – | –† | NE |
| RAJI | – | – | – | ++ | NE |
| NKTL | |||||
| DERL-7 | – | + | – | +† | NE |
| Other BCL | |||||
| 380 | NE | NE | NE | +† | NE |
| AMO-I | NE | – | – | ++† | NE |
| CI-I | + | – | – | ++† | NE |
| CRO-AP3 | – | + | – | –† | NE |
| JVM-13 | – | + | – | –† | NE |
| L-591 | – | – | – | ++† | NE |
| LP-1 | – | – | – | –† | NE |
| MC-116 | + | – | – | +† | NE |
| MUTZ-5 | NE | + | – | NE† | NE |
| NALM-6 | NE | – | – | NE† | NE |
| SU-DHL-16 | – | – | – | –† | – |
| TANOUE | – | – | – | –† | NE |
| TS-2 | NE | – | NE | NE† | NE |
| U-266 | – | – | – | ++† | NE |
| U-698 | – | – | NE | NE† | NE |
| TCL | |||||
| ALL-SIL | – | – | – | –† | – |
| CCRF-CEM | – | – | – | +† | – |
| HD-MAR | – | – | – | –† | – |
| HPB-ALL | – | – | – | –† | NE |
| KE-37 | – | – | – | ++† | NE |
| MOLT-4 | – | NE | NE | +† | – |
| MOLT-14 | – | – | – | +† | – |
| PEER | NE | – | – | +† | NE |
| TALL-1 | – | – | – | +† | NE |
| TALL-104 | NE | – | NE | NE† | NE |
| Myeloid | |||||
| CMK-1 | – | – | – | ++† | NE |
| GDM-1 | + | – | + | ++† | – |
| HD-MYZ | – | – | – | NE† | NE |
| HL60 | – | – | – | –† | NE |
| HMC-1 | – | + | NE | +† | + |
| K-562 | – | + | NE | ++† | NE |
| KASUMI-1 | – | – | – | –† | NE |
| KG-1 | + | + | – | –† | NE |
| M-07e | – | – | – | ++† | NE |
| MonoMac-1 | – | – | – | –† | – |
| MOLM-16 | – | + | NE | NE† | NE |
| MOLM-17 | + | – | NE | +† | NE |
| MUTZ-2 | – | – | – | –† | NE |
| MUTZ-3 | – | – | – | –† | NE |
| MUTZ-11 | – | NE | NE | +† | + |
| NB-4 | – | – | – | –† | – |
| NOMO-1 | – | – | – | +† | NE |
| OCIAML2 | + | – | – | –† | NE |
| TF-1 | – | + | – | –† | – |
| THP-1 | – | – | – | +† | NE |
| U-937 | – | – | – | –† | NE |
| Controls | |||||
| CD34+ | + | – | – | ++ | NE |
| MRC-5 | – | – | – | NE | NE |
| NC-NC | – | – | – | + | NE |
| PBC | + | – | – | ++ | – |
| Solid tumors | |||||
| 293 | – | + | – | + | NE |
| BPH-1 | – | NE | – | – | NE |
| CAPAN-1 | – | – | – | – | NE |
| HELA | – | – | + | + | NE |
| HT-1080 | – | + | NE | + | NE |
| LN-405 | NE | + | NE | – | NE |
| LN-CAP | – | NE | + | NE | NE |
| NTERA2 | – | – | – | – | NE |
| PC-3 | NE | + | + | NE | NE |
| . | HOP . | HOXB9 . | HLXB9 . | HOXB4* . | mir-196a1 . |
|---|---|---|---|---|---|
| HL | |||||
| HD-70 | NE† | +† | NE† | +† | NE† |
| HDLM-2 | +† | +† | +† | +† | +† |
| KM-H2 | +† | +† | +† | ++† | +† |
| L-1236 | –† | +† | +† | ++† | +† |
| L-428 | –† | +† | +† | ++† | +† |
| L-540 | +† | +† | –† | +† | +† |
| SUP-HD1 | +† | +† | +† | ++† | +† |
| ALCL | |||||
| DEL | – | –† | +† | +† | NE† |
| FE-PD | NE | +† | –† | NE† | NE† |
| KARPAS-299 | – | +† | –† | +† | +† |
| JB6 | – | –† | +† | +† | NE† |
| KI-JK | – | –† | +† | +† | NE† |
| MAC2A | – | +† | +† | +† | NE† |
| SR-786 | – | –† | +† | +† | +† |
| SU-DHLI | NE | +† | NE† | NE† | NE† |
| SUP-M2 | + | +† | +† | ++† | +† |
| MLBCL | |||||
| KARPAS-1106P | NE | +† | –† | +† | NE |
| MedB-1 | – | +† | +† | +† | NE |
| DLCL/FL | |||||
| DB | – | – | +† | – | NE |
| DOHH2 | – | – | +† | – | NE |
| KARPAS-422 | – | – | +† | + | – |
| KIS-1 | NE | – | –† | + | – |
| OCI-LY-19 | NE | – | +† | NE | NE |
| RC-K8 | – | + | +† | – | + |
| RI-1 | – | – | +† | – | – |
| SBH-1 | – | – | +† | NE | NE |
| SC-1 | – | – | +† | – | – |
| SU-DHL-4 | – | – | –† | – | NE |
| WSU-NHL | – | – | –† | – | NE |
| MCL | |||||
| GRANTA-519 | NE | + | – | +† | NE |
| JEKO-1 | – | – | – | +† | NE |
| BL | |||||
| BL-41 | – | – | – | +† | – |
| BL-70 | – | – | – | –† | – |
| DAUDI | – | – | – | ++† | – |
| DG-75 | NE | – | – | NE† | NE |
| NAMALWA | – | + | – | –† | NE |
| RAJI | – | – | – | ++ | NE |
| NKTL | |||||
| DERL-7 | – | + | – | +† | NE |
| Other BCL | |||||
| 380 | NE | NE | NE | +† | NE |
| AMO-I | NE | – | – | ++† | NE |
| CI-I | + | – | – | ++† | NE |
| CRO-AP3 | – | + | – | –† | NE |
| JVM-13 | – | + | – | –† | NE |
| L-591 | – | – | – | ++† | NE |
| LP-1 | – | – | – | –† | NE |
| MC-116 | + | – | – | +† | NE |
| MUTZ-5 | NE | + | – | NE† | NE |
| NALM-6 | NE | – | – | NE† | NE |
| SU-DHL-16 | – | – | – | –† | – |
| TANOUE | – | – | – | –† | NE |
| TS-2 | NE | – | NE | NE† | NE |
| U-266 | – | – | – | ++† | NE |
| U-698 | – | – | NE | NE† | NE |
| TCL | |||||
| ALL-SIL | – | – | – | –† | – |
| CCRF-CEM | – | – | – | +† | – |
| HD-MAR | – | – | – | –† | – |
| HPB-ALL | – | – | – | –† | NE |
| KE-37 | – | – | – | ++† | NE |
| MOLT-4 | – | NE | NE | +† | – |
| MOLT-14 | – | – | – | +† | – |
| PEER | NE | – | – | +† | NE |
| TALL-1 | – | – | – | +† | NE |
| TALL-104 | NE | – | NE | NE† | NE |
| Myeloid | |||||
| CMK-1 | – | – | – | ++† | NE |
| GDM-1 | + | – | + | ++† | – |
| HD-MYZ | – | – | – | NE† | NE |
| HL60 | – | – | – | –† | NE |
| HMC-1 | – | + | NE | +† | + |
| K-562 | – | + | NE | ++† | NE |
| KASUMI-1 | – | – | – | –† | NE |
| KG-1 | + | + | – | –† | NE |
| M-07e | – | – | – | ++† | NE |
| MonoMac-1 | – | – | – | –† | – |
| MOLM-16 | – | + | NE | NE† | NE |
| MOLM-17 | + | – | NE | +† | NE |
| MUTZ-2 | – | – | – | –† | NE |
| MUTZ-3 | – | – | – | –† | NE |
| MUTZ-11 | – | NE | NE | +† | + |
| NB-4 | – | – | – | –† | – |
| NOMO-1 | – | – | – | +† | NE |
| OCIAML2 | + | – | – | –† | NE |
| TF-1 | – | + | – | –† | – |
| THP-1 | – | – | – | +† | NE |
| U-937 | – | – | – | –† | NE |
| Controls | |||||
| CD34+ | + | – | – | ++ | NE |
| MRC-5 | – | – | – | NE | NE |
| NC-NC | – | – | – | + | NE |
| PBC | + | – | – | ++ | – |
| Solid tumors | |||||
| 293 | – | + | – | + | NE |
| BPH-1 | – | NE | – | – | NE |
| CAPAN-1 | – | – | – | – | NE |
| HELA | – | – | + | + | NE |
| HT-1080 | – | + | NE | + | NE |
| LN-405 | NE | + | NE | – | NE |
| LN-CAP | – | NE | + | NE | NE |
| NTERA2 | – | – | – | – | NE |
| PC-3 | NE | + | + | NE | NE |
ALCL indicates anaplastic large cell lymphoma; MLBCL, mediastinal large B-cell lymphoma; DLBCL, diffuse large B-cell lymphoma; FL, follicular lymphoma; MBCL, mediastinal B-cell lymphoma; BL, Burkitt lymphoma; NKTL, natural killer T-cell lymphoma; BCL, B-cell lymphoma/leukemia; TCL, T-cell leukemia; PBC, peripheral blood cells (PBCs); NE, no tested expression; +, positive expression; ++, strong expression; –, negative expression.
HOXB4 expression was judged quantitatively.
Lymphoma/leukemia entities with at least 50% positive tested cell lines.