Lung histologic features of pulmonary hypertension
| Feature . | Sickle mice . | Hemizygous mice . |
|---|---|---|
| Number of mice | 8 | 9 |
| Histology score | ||
| Thrombi, emboli | 0 | 0 |
| Plexiform vascular lesion | 0 | 0 |
| Vascular congestion | 3.9 ± 0.8 | 3.0 ± 0.8 |
| Capillary dilation | 3.6 ± 1.0 | 2.4 ± 0.7 |
| Large vessel dilation | 3.2 ± 1.0 | 2.7 ± 0.9 |
| Intravascular leukocytes | 3.1 ± 0.6* | 1.3 ± 0.2 |
| Intra-alveolar leukocytes | 1.0 ± 0.5 | 0.2 ± 0.2 |
| Arterial wall thickness, μm | ||
| Large pulmonary arteries | 14.3 ± 1.2 | 12.6 ± 0.8 |
| Small pulmonary arteries | 2.8 ± 0.3 | 2.4 ± 0.3 |
| Feature . | Sickle mice . | Hemizygous mice . |
|---|---|---|
| Number of mice | 8 | 9 |
| Histology score | ||
| Thrombi, emboli | 0 | 0 |
| Plexiform vascular lesion | 0 | 0 |
| Vascular congestion | 3.9 ± 0.8 | 3.0 ± 0.8 |
| Capillary dilation | 3.6 ± 1.0 | 2.4 ± 0.7 |
| Large vessel dilation | 3.2 ± 1.0 | 2.7 ± 0.9 |
| Intravascular leukocytes | 3.1 ± 0.6* | 1.3 ± 0.2 |
| Intra-alveolar leukocytes | 1.0 ± 0.5 | 0.2 ± 0.2 |
| Arterial wall thickness, μm | ||
| Large pulmonary arteries | 14.3 ± 1.2 | 12.6 ± 0.8 |
| Small pulmonary arteries | 2.8 ± 0.3 | 2.4 ± 0.3 |
Histology scores range from 0 to 6; numbers are mean ± SEM.
P < .01 by t test.