Level of donor chimerism in PBMC subsets in the sex-matched control and DBY-Treg groups at day 300
. | Controls . | . | . | DBY-Tregs . | . | . | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| . | Cells by origin, % . | . | . | Cells by origin, % . | . | . | ||||
| PBMC subset . | Donor . | Host . | Chimerism, % . | Donor . | Host . | Chimerism, % . | ||||
| CD3 | 1.6 ± 0.5 | 17.4 ± 2.8 | 8.6 ± 2.9 | 1.4 ± 0.3 | 19.9 ± 2.1 | 6.4 ± 0.8 | ||||
| B220 | 16.5 ± 2.0 | 37.8 ± 3.1 | 30.5 ± 3.6 | 15.5 ± 1.8 | 38.2 ± 1.8 | 28.7 ± 2.4 | ||||
| CD11b | 3.9 ± 0.9 | 18.3 ± 1.6 | 17.6 ± 3.1 | 3.1 ± 0.4 | 17.0 ± 2.4 | 15.7 ± 0.3 | ||||
| Gr1 | 2.4 ± 0.6 | 8.4 ± 0.9 | 22.1 ± 5.4 | 1.9 ± 0.4 | 7.9 ± 1.6 | 19.5 ± 1.9 | ||||
| Global | — | — | 23.5 ± 2.5 | — | — | 20.8 ± 1.6 | ||||
. | Controls . | . | . | DBY-Tregs . | . | . | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| . | Cells by origin, % . | . | . | Cells by origin, % . | . | . | ||||
| PBMC subset . | Donor . | Host . | Chimerism, % . | Donor . | Host . | Chimerism, % . | ||||
| CD3 | 1.6 ± 0.5 | 17.4 ± 2.8 | 8.6 ± 2.9 | 1.4 ± 0.3 | 19.9 ± 2.1 | 6.4 ± 0.8 | ||||
| B220 | 16.5 ± 2.0 | 37.8 ± 3.1 | 30.5 ± 3.6 | 15.5 ± 1.8 | 38.2 ± 1.8 | 28.7 ± 2.4 | ||||
| CD11b | 3.9 ± 0.9 | 18.3 ± 1.6 | 17.6 ± 3.1 | 3.1 ± 0.4 | 17.0 ± 2.4 | 15.7 ± 0.3 | ||||
| Gr1 | 2.4 ± 0.6 | 8.4 ± 0.9 | 22.1 ± 5.4 | 1.9 ± 0.4 | 7.9 ± 1.6 | 19.5 ± 1.9 | ||||
| Global | — | — | 23.5 ± 2.5 | — | — | 20.8 ± 1.6 | ||||
For control mice (female into female), n=3; for DBY-Treg—treated mice (5 weekly injections), n = 5.