Transcripts encoding transmembrane domain containing proteins up-regulated in megakaryocytes
| Gene ID . | Gene name . | Fold difference, MK/EB . |
|---|---|---|
| Integrins | ||
| ITGB3 | Platelet membrane glycoprotein IIIa | 43.3 |
| ITGA2B | Platelet membrane glycoprotein IIb | 31.5 |
| ITGA6 | Integrin α-6 precursor | 6.5 |
| Immunoglobulin superfamily members | ||
| PECAM1 | Platelet endothelial cell adhesion molecule | 47.3 |
| CD84 | CD84 antigen | 12.3 |
| C6orf25* | G6B protein | 10.4 |
| VSIG2 | V-set and immunoglobulin domain containing 2 | 10.1 |
| C6orf21* | G6F protein | 9.2 |
| FCER1A | High-affinity immunoglobulin ε receptor α-subunit precursor | 6.3 |
| G protein-coupled receptors | ||
| SUCNR1* | G protein-coupled receptor 91 (GPR91) | 7.2 |
| GPR171 | Probable G protein-coupled receptor H963 | 2.7 |
| GPR56 | G protein-coupled receptor 56 | 2.0 |
| Tetraspannins | ||
| CD9 | CD9 antigen | 23.9 |
| TSPAN15* | Tetraspan NET-7 | 19.0 |
| PHEMX* | Phemx protein | 3.3 |
| TSPAN18 | Tetraspanin similar to uroplakin 1 | 2.8 |
| TSN9 | Tetraspan NET-5 | 2.6 |
| Adaptor molecules | ||
| FCER1G | High-affinity immunoglobulin ε receptor γ-subunit | 16.0 |
| LAT2* | WBSCR5 protein, LAT2 | 13.1 |
| LAT | Linker for activation of T cells | 8.0 |
| Leucine-rich repeat proteins | ||
| GP9 | Platelet glycoprotein IX | 48.6 |
| GP1BA | Platelet glycoprotein Ib α | 23.1 |
| RTN4R | Reticulon 4 | 3.4 |
| TLR9 | Toll-like receptor 9 | 2.3 |
| Other transmembrane domain-containing proteins | ||
| PF4 | Platelet factor 4 | 111.3 |
| SELP | P-selectin | 71.0 |
| PPBP | Platelet basic protein | 62.7 |
| TMEM40 | Transmembrane protein 40 | 19.8 |
| LST1* | Leukocyte-specific transcript 1 protein (B144 protein) | 19.7 |
| GJA4 | Gap junction α-4 | 15.1 |
| PLXDC2 | Plexin domain-containing 2 | 13.1 |
| CAV1 | Caveolin-1 | 10.3 |
| MEST | Mesoderm-specific transcript | 8.6 |
| EPHNB1 | Ephrin-B1 | 8.2 |
| SLC44A1 | CDW92 antigen | 6.6 |
| HG2A | CD74 antigen | 6.3 |
| CD40 | Tumor necrosis factor receptor superfamily member 5, CD40L receptor | 6.0 |
| CCL5 | Small inducible cytokine A5 | 5.6 |
| ANPEP | Aminopeptidase N (myeloid plasma membrane glycoprotein CD13) | 5.6 |
| CAV2 | Caveolin-2 | 5.5 |
| CD69 | CD69 antigen | 4.7 |
| NINJ2 | Ninjurin 2 | 4.3 |
| LY6G5C | G5C protein | 3.7 |
| TNFRSF14 | Tumor necrosis factor receptor superfamily member 14 | 3.4 |
| PTAFR | Platelet-activating factor receptor | 2.9 |
| IL9R | Interleukin-9 receptor | 2.8 |
| ICAM2 | Intercellular adhesion molecule-2 (CD102 antigen) | 2.6 |
| ADAM10 | ADAM 10 | 2.5 |
| NPR3 | Atrial natriuretic peptide clearance receptor | 2.5 |
| TREML2 | Triggering receptor expressed on myeloid cells-like 2 | 2.2 |
| Gene ID . | Gene name . | Fold difference, MK/EB . |
|---|---|---|
| Integrins | ||
| ITGB3 | Platelet membrane glycoprotein IIIa | 43.3 |
| ITGA2B | Platelet membrane glycoprotein IIb | 31.5 |
| ITGA6 | Integrin α-6 precursor | 6.5 |
| Immunoglobulin superfamily members | ||
| PECAM1 | Platelet endothelial cell adhesion molecule | 47.3 |
| CD84 | CD84 antigen | 12.3 |
| C6orf25* | G6B protein | 10.4 |
| VSIG2 | V-set and immunoglobulin domain containing 2 | 10.1 |
| C6orf21* | G6F protein | 9.2 |
| FCER1A | High-affinity immunoglobulin ε receptor α-subunit precursor | 6.3 |
| G protein-coupled receptors | ||
| SUCNR1* | G protein-coupled receptor 91 (GPR91) | 7.2 |
| GPR171 | Probable G protein-coupled receptor H963 | 2.7 |
| GPR56 | G protein-coupled receptor 56 | 2.0 |
| Tetraspannins | ||
| CD9 | CD9 antigen | 23.9 |
| TSPAN15* | Tetraspan NET-7 | 19.0 |
| PHEMX* | Phemx protein | 3.3 |
| TSPAN18 | Tetraspanin similar to uroplakin 1 | 2.8 |
| TSN9 | Tetraspan NET-5 | 2.6 |
| Adaptor molecules | ||
| FCER1G | High-affinity immunoglobulin ε receptor γ-subunit | 16.0 |
| LAT2* | WBSCR5 protein, LAT2 | 13.1 |
| LAT | Linker for activation of T cells | 8.0 |
| Leucine-rich repeat proteins | ||
| GP9 | Platelet glycoprotein IX | 48.6 |
| GP1BA | Platelet glycoprotein Ib α | 23.1 |
| RTN4R | Reticulon 4 | 3.4 |
| TLR9 | Toll-like receptor 9 | 2.3 |
| Other transmembrane domain-containing proteins | ||
| PF4 | Platelet factor 4 | 111.3 |
| SELP | P-selectin | 71.0 |
| PPBP | Platelet basic protein | 62.7 |
| TMEM40 | Transmembrane protein 40 | 19.8 |
| LST1* | Leukocyte-specific transcript 1 protein (B144 protein) | 19.7 |
| GJA4 | Gap junction α-4 | 15.1 |
| PLXDC2 | Plexin domain-containing 2 | 13.1 |
| CAV1 | Caveolin-1 | 10.3 |
| MEST | Mesoderm-specific transcript | 8.6 |
| EPHNB1 | Ephrin-B1 | 8.2 |
| SLC44A1 | CDW92 antigen | 6.6 |
| HG2A | CD74 antigen | 6.3 |
| CD40 | Tumor necrosis factor receptor superfamily member 5, CD40L receptor | 6.0 |
| CCL5 | Small inducible cytokine A5 | 5.6 |
| ANPEP | Aminopeptidase N (myeloid plasma membrane glycoprotein CD13) | 5.6 |
| CAV2 | Caveolin-2 | 5.5 |
| CD69 | CD69 antigen | 4.7 |
| NINJ2 | Ninjurin 2 | 4.3 |
| LY6G5C | G5C protein | 3.7 |
| TNFRSF14 | Tumor necrosis factor receptor superfamily member 14 | 3.4 |
| PTAFR | Platelet-activating factor receptor | 2.9 |
| IL9R | Interleukin-9 receptor | 2.8 |
| ICAM2 | Intercellular adhesion molecule-2 (CD102 antigen) | 2.6 |
| ADAM10 | ADAM 10 | 2.5 |
| NPR3 | Atrial natriuretic peptide clearance receptor | 2.5 |
| TREML2 | Triggering receptor expressed on myeloid cells-like 2 | 2.2 |
Transcripts are ranked within each structural category by the fold difference in expression between MKs and EBs as detected using cDNA microarrays.
Transcripts were selected for further analysis.