Table 2

Multivariate Cox model for DFS

FeatureUnivariate analysis, PMultivariate analysis, P
Global series 
    WNT methylation < .001 < .001 
    WBC count greater than 50 × 109/L .006 .05 
    BCR-ABL positivity < .001 < .001 
    T phenotype .05 NS 
    Age older than 15 y .001 .003 
    PETHEMA poor risk .05 NS 
Childhood ALL   
    WNT methylation < .001 .001 
    NCI poor risk .04 NS 
    T phenotype .04 NS 
    WBC count greater than 50 × 109/L .03 NS 
Adult ALL   
    WNT methylation .005 .004 
    T phenotype .05 NS 
    WBC count greater than 50 × 109/L .05 NS 
    BCR-ABL positivity <.001 .001 
FeatureUnivariate analysis, PMultivariate analysis, P
Global series 
    WNT methylation < .001 < .001 
    WBC count greater than 50 × 109/L .006 .05 
    BCR-ABL positivity < .001 < .001 
    T phenotype .05 NS 
    Age older than 15 y .001 .003 
    PETHEMA poor risk .05 NS 
Childhood ALL   
    WNT methylation < .001 .001 
    NCI poor risk .04 NS 
    T phenotype .04 NS 
    WBC count greater than 50 × 109/L .03 NS 
Adult ALL   
    WNT methylation .005 .004 
    T phenotype .05 NS 
    WBC count greater than 50 × 109/L .05 NS 
    BCR-ABL positivity <.001 .001 
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