Factors affecting mortality from all causes in males in the United Kingdom with hemophilia A or B who were not infected with HIV, 1977 to 1999
| . | Severe hemophilia . | Moderate/mild hemophilia . | ||||
|---|---|---|---|---|---|---|
| No. of deaths* . | Death rate ratio† . | 95% CI‡ . | No. of deaths* . | Death rate ratio† . | 95% CI . | |
| Type of hemophilia | ||||||
| A§ | 213 | 1.00 | — | 470 | 1.00 | — |
| B | 33 | 0.71 | 0.49-1.04 | 90 | 0.96 | 0.77-1.21 |
| P for difference | — | .07 | — | — | .75 | — |
| Calendar period | ||||||
| 1977-1984‡ | 108 | 1.00 | — | 146 | 1.00 | — |
| 1985-1992 | 69 | 0.96 | 0.71-1.30 | 191 | 0.81 | 0.65-1.01 |
| 1993-1999 | 69 | 0.96 | 0.71-1.31 | 223 | 0.79 | 0.64-0.98 |
| P for trend | — | .78 | — | — | .05 | — |
| Total deaths* | 246 | — | — | 560 | — | — |
| Person-years* | 27 099 | — | — | 71 651 | — | — |
| . | Severe hemophilia . | Moderate/mild hemophilia . | ||||
|---|---|---|---|---|---|---|
| No. of deaths* . | Death rate ratio† . | 95% CI‡ . | No. of deaths* . | Death rate ratio† . | 95% CI . | |
| Type of hemophilia | ||||||
| A§ | 213 | 1.00 | — | 470 | 1.00 | — |
| B | 33 | 0.71 | 0.49-1.04 | 90 | 0.96 | 0.77-1.21 |
| P for difference | — | .07 | — | — | .75 | — |
| Calendar period | ||||||
| 1977-1984‡ | 108 | 1.00 | — | 146 | 1.00 | — |
| 1985-1992 | 69 | 0.96 | 0.71-1.30 | 191 | 0.81 | 0.65-1.01 |
| 1993-1999 | 69 | 0.96 | 0.71-1.31 | 223 | 0.79 | 0.64-0.98 |
| P for trend | — | .78 | — | — | .05 | — |
| Total deaths* | 246 | — | — | 560 | — | — |
| Person-years* | 27 099 | — | — | 71 651 | — | — |
HIV-positive patients were excluded from 1985 or date of seroconversion, if later.
—indicates not applicable.
Deaths and person-years at ages 85+ years excluded.
Adjusted for age, whether the patient had ever developed inhibitors, and either calendar period (analyses of type of hemophilia) or type of hemophilia (analyses of calendar period).
Confidence interval.
Baseline category.