Age-specific mortality rates for deaths involving bleeding or intracranial hemorrhage in males in the United Kingdom with hemophilia A or B who were not infected with HIV, 1977 to 1999
| Age, y . | Severe hemophilia . | Moderate/mild hemophilia . | ||||||
|---|---|---|---|---|---|---|---|---|
| No. of deaths . | Death rate per 1000 y . | 95% CI* . | No. of deaths . | Death rate per 1000 y . | 95% CI . | |||
| Total . | No. with inhibitors . | Total . | No. with inhibitors . | |||||
| Deaths involving bleeding of any type | ||||||||
| 0-4 | 11 | 2 | 4.3 | 2.4-7.8 | 3 | 0 | 0.8 | 0.2-2.4 |
| 5-14 | 2 | 1 | 0.3 | 0.1-1.3 | 2 | 1 | 0.2 | 0.0-0.7 |
| 15-24 | 9 | 4 | 1.6 | 0.8-3.1 | 4 | 0 | 0.3 | 0.1-0.8 |
| 25-34 | 15 | 5 | 3.1 | 1.9-5.1 | 5 | 2 | 0.4 | 0.2-0.9 |
| 35-44 | 22 | 9 | 6.3 | 4.2-9.6 | 11 | 1 | 1.1 | 0.6-1.9 |
| 45-54 | 26 | 6 | 11.3 | 7.7-16.5 | 18 | 0 | 2.2 | 1.4-3.6 |
| 55-64 | 26 | 11 | 20.0 | 13.6-29.3 | 35 | 3 | 5.7 | 4.1-7.9 |
| 65-74 | 23 | 7 | 37.4 | 24.9-56.3 | 53 | 1 | 13.1 | 10.0-17.2 |
| 75-84 | 11 | 3 | 58.5 | 32.4-105.7 | 29 | 2 | 18.4 | 12.8-26.5 |
| Total | 145 | 48 | — | — | 160 | 10 | — | — |
| Deaths involving intracranial hemorrhage | ||||||||
| 0-4 | 11 | 2 | 4.3 | 2.4-7.8 | 3 | 0 | 0.8 | 0.2-2.4 |
| 5-14 | 1 | 1 | 0.2 | 0.0-1.2 | 1 | 1 | 0.1 | 0.0-0.6 |
| 15-24 | 4 | 1 | 0.7 | 0.3-1.9 | 3 | 0 | 0.2 | 0.1-0.7 |
| 25-34 | 9 | 2 | 1.9 | 1.0-3.6 | 1 | 0 | 0.1 | 0.0-0.6 |
| 35-44 | 12 | 4 | 3.4 | 2.0-6.1 | 7 | 0 | 0.7 | 0.3-1.4 |
| 45-54 | 13 | 2 | 5.6 | 3.3-9.7 | 10 | 0 | 1.2 | 0.7-2.3 |
| 55-64 | 16 | 6 | 12.3 | 7.5-20.1 | 21 | 1 | 3.4 | 2.2-5.2 |
| 65-74 | 13 | 3 | 21.1 | 12.3-36.4 | 28 | 1 | 6.9 | 4.8-10.0 |
| 75-84 | 5 | 2 | 26.6 | 11.1-63.9 | 10 | 1 | 6.4 | 3.4-11.8 |
| Total | 84 | 23 | — | — | 84 | 4 | — | — |
| Age, y . | Severe hemophilia . | Moderate/mild hemophilia . | ||||||
|---|---|---|---|---|---|---|---|---|
| No. of deaths . | Death rate per 1000 y . | 95% CI* . | No. of deaths . | Death rate per 1000 y . | 95% CI . | |||
| Total . | No. with inhibitors . | Total . | No. with inhibitors . | |||||
| Deaths involving bleeding of any type | ||||||||
| 0-4 | 11 | 2 | 4.3 | 2.4-7.8 | 3 | 0 | 0.8 | 0.2-2.4 |
| 5-14 | 2 | 1 | 0.3 | 0.1-1.3 | 2 | 1 | 0.2 | 0.0-0.7 |
| 15-24 | 9 | 4 | 1.6 | 0.8-3.1 | 4 | 0 | 0.3 | 0.1-0.8 |
| 25-34 | 15 | 5 | 3.1 | 1.9-5.1 | 5 | 2 | 0.4 | 0.2-0.9 |
| 35-44 | 22 | 9 | 6.3 | 4.2-9.6 | 11 | 1 | 1.1 | 0.6-1.9 |
| 45-54 | 26 | 6 | 11.3 | 7.7-16.5 | 18 | 0 | 2.2 | 1.4-3.6 |
| 55-64 | 26 | 11 | 20.0 | 13.6-29.3 | 35 | 3 | 5.7 | 4.1-7.9 |
| 65-74 | 23 | 7 | 37.4 | 24.9-56.3 | 53 | 1 | 13.1 | 10.0-17.2 |
| 75-84 | 11 | 3 | 58.5 | 32.4-105.7 | 29 | 2 | 18.4 | 12.8-26.5 |
| Total | 145 | 48 | — | — | 160 | 10 | — | — |
| Deaths involving intracranial hemorrhage | ||||||||
| 0-4 | 11 | 2 | 4.3 | 2.4-7.8 | 3 | 0 | 0.8 | 0.2-2.4 |
| 5-14 | 1 | 1 | 0.2 | 0.0-1.2 | 1 | 1 | 0.1 | 0.0-0.6 |
| 15-24 | 4 | 1 | 0.7 | 0.3-1.9 | 3 | 0 | 0.2 | 0.1-0.7 |
| 25-34 | 9 | 2 | 1.9 | 1.0-3.6 | 1 | 0 | 0.1 | 0.0-0.6 |
| 35-44 | 12 | 4 | 3.4 | 2.0-6.1 | 7 | 0 | 0.7 | 0.3-1.4 |
| 45-54 | 13 | 2 | 5.6 | 3.3-9.7 | 10 | 0 | 1.2 | 0.7-2.3 |
| 55-64 | 16 | 6 | 12.3 | 7.5-20.1 | 21 | 1 | 3.4 | 2.2-5.2 |
| 65-74 | 13 | 3 | 21.1 | 12.3-36.4 | 28 | 1 | 6.9 | 4.8-10.0 |
| 75-84 | 5 | 2 | 26.6 | 11.1-63.9 | 10 | 1 | 6.4 | 3.4-11.8 |
| Total | 84 | 23 | — | — | 84 | 4 | — | — |
Includes all deaths with bleeding/intracranial hemorrhage mentioned on the death certificate or notified by the hemophilia center. HIV-positive patients were excluded from 1985 or date of seroconversion, if later.
— indicates not applicable.
Confidence interval.