Altered IFN-γ and TNF-α release in CD25+ Treg cells after suppressed galectin-10 expression
| Population . | IFN-γ, median pg/mL (range) . | TFN-α, medan pg/mL (range) . |
|---|---|---|
| CD4+ | 3013* (929-<5000) | 538* (350-803) |
| CD25+ Ø | 128* (57-224) | 16* (10-20) |
| CD25+ SC | 177 (76-354) | 19 (12-25) |
| CD25+ Gal-10 | 825* (324-1558) | 55* (39-81) |
| CD4+ + CCD25+ Ø | 343 (117-558) | 17 (11-23) |
| CD4+ + CD25+ SC | 421 (200-684) | 21 (13-27) |
| CD4+ + CD25+ Gal-10 | 2290* (719-4518) | 89* (60-133) |
| Population . | IFN-γ, median pg/mL (range) . | TFN-α, medan pg/mL (range) . |
|---|---|---|
| CD4+ | 3013* (929-<5000) | 538* (350-803) |
| CD25+ Ø | 128* (57-224) | 16* (10-20) |
| CD25+ SC | 177 (76-354) | 19 (12-25) |
| CD25+ Gal-10 | 825* (324-1558) | 55* (39-81) |
| CD4+ + CCD25+ Ø | 343 (117-558) | 17 (11-23) |
| CD4+ + CD25+ SC | 421 (200-684) | 21 (13-27) |
| CD4+ + CD25+ Gal-10 | 2290* (719-4518) | 89* (60-133) |
Data are the results of 4 independent experiments performed as shown in Figure 5. Cytokine release was determined in supernatants derived from CFSE stimulation cultures on day 3, using human Cytometric Bead Array.