Multivariate analysis of baseline parameters and before cycle 2 percentage SFLC reduction associated with event-free and overall survival
| Variable . | n/N (%) . | HR (95% CI) . | P . |
|---|---|---|---|
| Overall survival from cycle 2 | |||
| Top-tertile % SFLC reduction, before cycle 2 | 95/286 (33) | 2.15 (1.03-4.47) | .041 |
| LDH of 190 U/L or higher | 74/286 (26) | 2.96 (1.41-6.22) | .004 |
| CAs | 94/286 (33) | 3.01 (1.40-6.45) | .005 |
| Event-free survival from cycle 2 | |||
| Top-tertile % SFLC reduction, before cycle 2 | 95/286 (33) | 1.96 (1.03-3.74) | .041 |
| LDH of 190 U/L or higher | 74/286 (26) | 2.38 (1.23-4.60) | .010 |
| CAs | 94/286 (33) | 2.62 (1.35-5.07) | .004 |
| Variable . | n/N (%) . | HR (95% CI) . | P . |
|---|---|---|---|
| Overall survival from cycle 2 | |||
| Top-tertile % SFLC reduction, before cycle 2 | 95/286 (33) | 2.15 (1.03-4.47) | .041 |
| LDH of 190 U/L or higher | 74/286 (26) | 2.96 (1.41-6.22) | .004 |
| CAs | 94/286 (33) | 3.01 (1.40-6.45) | .005 |
| Event-free survival from cycle 2 | |||
| Top-tertile % SFLC reduction, before cycle 2 | 95/286 (33) | 1.96 (1.03-3.74) | .041 |
| LDH of 190 U/L or higher | 74/286 (26) | 2.38 (1.23-4.60) | .010 |
| CAs | 94/286 (33) | 2.62 (1.35-5.07) | .004 |
P value from Wald chi-square test in Cox regression analysis. Multivariate model uses stepwise selection with entry level .1 and variable remains if meets the .05 level.
HR indicates hazard ratio; 95% CI, 95% confidence interval.