Characteristics of patients and controls at the test time, unless otherwise specified
| . | Controls, n = 23 . | Cases, n = 88 . | |||
|---|---|---|---|---|---|
| Group A, n = 34 . | Group B, n = 62* . | ||||
| C282Y/C282Y, n = 19 . | C282Y/H63D, n = 15 . | C282Y/C282Y, n = 46 . | C282Y/H63D, n = 16 . | ||
| Sex, M/F | 19/4 | 12/7 | 12/3 | 36/10 | 15/1 |
| Mean age, y (±SD) | 36 (±10)† | 45 (±14) | 46 (±15) | 50 (±13) | 51 (±13) |
| Hb, g/L | 147 (142-153) | 148 (143-152) | 149 (143-155) | 149 (146-152) | 150 (144-156) |
| Basal TS, % | 26.3 (23.7-29.1) | 84.1 (78.9-89.5) ‡ | 48.4 (41.4-56.6) | 38.6 (34.2-43.6) | 34.1 (27.9-41.6) |
| Basal SF, μg/L | 85.7 (60.9-120.6) | 734.4 (437.7-1232) | 567.9 (415-777) | 29.5 (24.8-35) | 54 (43.5-67.2) |
| Iron removed, g | — | — | — | 4.98 (3.9-6.1)‡ | 2.56 (2.1-3.2) |
| TS at diagnosis, % | — | — | — | 79.6 (75-84)‡ | 52.7 (45.7-60.7) |
| SF at diagnosis, μg/L | — | — | — | 897.4 (691.1-1165) | 667.3 (569.3-782.3) |
| . | Controls, n = 23 . | Cases, n = 88 . | |||
|---|---|---|---|---|---|
| Group A, n = 34 . | Group B, n = 62* . | ||||
| C282Y/C282Y, n = 19 . | C282Y/H63D, n = 15 . | C282Y/C282Y, n = 46 . | C282Y/H63D, n = 16 . | ||
| Sex, M/F | 19/4 | 12/7 | 12/3 | 36/10 | 15/1 |
| Mean age, y (±SD) | 36 (±10)† | 45 (±14) | 46 (±15) | 50 (±13) | 51 (±13) |
| Hb, g/L | 147 (142-153) | 148 (143-152) | 149 (143-155) | 149 (146-152) | 150 (144-156) |
| Basal TS, % | 26.3 (23.7-29.1) | 84.1 (78.9-89.5) ‡ | 48.4 (41.4-56.6) | 38.6 (34.2-43.6) | 34.1 (27.9-41.6) |
| Basal SF, μg/L | 85.7 (60.9-120.6) | 734.4 (437.7-1232) | 567.9 (415-777) | 29.5 (24.8-35) | 54 (43.5-67.2) |
| Iron removed, g | — | — | — | 4.98 (3.9-6.1)‡ | 2.56 (2.1-3.2) |
| TS at diagnosis, % | — | — | — | 79.6 (75-84)‡ | 52.7 (45.7-60.7) |
| SF at diagnosis, μg/L | — | — | — | 897.4 (691.1-1165) | 667.3 (569.3-782.3) |
Data are presented as GM (95% CI) unless specified otherwise.
TS indicates transferrin saturation; SF, serum ferritin; Hb, hemoglobin; and —, not available.
Group B includes 8 patients of group A studied after iron depletion.
P < .01 versus A and P < .001 versus B.
P < .001 versus compound heterozygotes.