Characteristics of the HCT recipient cohort at the Fred Hutchinson Cancer Research Center, winter/spring seasons of December 2000-June 2004 (N = 122)
| Characteristic . | No. . |
|---|---|
| Median age, y (range) | 47 (1-71) |
| Sex, male, no. (%) | 73 (60) |
| HCT donor type, no. (%) | |
| Autologous/syngeneic | 22 (18) |
| Matched sibling | 42 (34) |
| Mismatched or unrelated | 58 (48) |
| Underlying disease, no. (%) | |
| Acute leukemia | 34 (28) |
| Chronic leukemia | 17 (14) |
| Myelodysplastic syndrome | 20 (16) |
| Non-Hodgkin lymphoma | 23 (19) |
| Multiple myeloma | 14 (11) |
| Other | 14 (11) |
| Underlying disease risk, no. (%)* | |
| Low | 19 (16) |
| Intermediate | 42 (34) |
| High | 61 (50) |
| Nonmyeloablative conditioning regimen† | 35/100 (35) |
| Stem cell source, no. (%) | |
| Bone marrow | 18 (15) |
| Peripheral blood | 103 (84) |
| Bone marrow and peripheral blood | 1 (1) |
| CMV serostatus, no. (%) | |
| Recipient seropositivity | 60 (49) |
| Donor seropositivity† | 40/100 (40) |
| Acute GvHD†, no. (%) | |
| Grade 0 or 1 | 38/100 (38) |
| Grade 2-4 | 62/100 (62) |
| Underlying seasonal allergies‡ | 35/111 (32) |
| Characteristic . | No. . |
|---|---|
| Median age, y (range) | 47 (1-71) |
| Sex, male, no. (%) | 73 (60) |
| HCT donor type, no. (%) | |
| Autologous/syngeneic | 22 (18) |
| Matched sibling | 42 (34) |
| Mismatched or unrelated | 58 (48) |
| Underlying disease, no. (%) | |
| Acute leukemia | 34 (28) |
| Chronic leukemia | 17 (14) |
| Myelodysplastic syndrome | 20 (16) |
| Non-Hodgkin lymphoma | 23 (19) |
| Multiple myeloma | 14 (11) |
| Other | 14 (11) |
| Underlying disease risk, no. (%)* | |
| Low | 19 (16) |
| Intermediate | 42 (34) |
| High | 61 (50) |
| Nonmyeloablative conditioning regimen† | 35/100 (35) |
| Stem cell source, no. (%) | |
| Bone marrow | 18 (15) |
| Peripheral blood | 103 (84) |
| Bone marrow and peripheral blood | 1 (1) |
| CMV serostatus, no. (%) | |
| Recipient seropositivity | 60 (49) |
| Donor seropositivity† | 40/100 (40) |
| Acute GvHD†, no. (%) | |
| Grade 0 or 1 | 38/100 (38) |
| Grade 2-4 | 62/100 (62) |
| Underlying seasonal allergies‡ | 35/111 (32) |
Low-risk diseases included chronic myeloid leukemia (CML) in chronic phase, refractory anemia, and aplastic anemia. Intermediate-risk diseases included CML in accelerated phase or in chronic phase after blast phase, acute leukemia or lymphoma in remission, refractory anemia with excess blasts, chronic lymphocytic leukemia, and paroxysmal nocturnal hemoglobinuria. High-risk diseases included CML in blast phase, juvenile CML, acute leukemia or lymphoma in relapse, newly diagnosed acute leukemia, refractory anemia with excess blasts in transformation, myeloma, immunodeficiency syndromes, renal cell carcinoma, and testicular carcinoma.
Characteristic applies to allogeneic transplantations only.
Excluding food and drug allergies. Allergy data were not available for 11 subjects.