Table 5 Percent of patients with very... | American Society of Hematology

Table 5

Percent of patients with very short or short telomeres in each leukocyte subset

Diagnosis	Granulocytes		Lymphocytes		Naïve T cells		Memory T cells		B cells		NK/NKT cells		Leukocytes
Diagnosis	<1%	1-10%	<1%	1-10%	<1%	1-10%	<1%	1-10%	<1%	1-10%	<1%	1-10%	<1%	1-10%
DC patients*	96*	4*	92*	8*	96*	4*	85*	8*	92*	8*	72*	20*	100*	0*
DC relatives*	16*	22*	4*	15*	6*	13*	4*	13*	4*	15*	2*	10*	9*	39*
FA†	40	33	13	20	13	19	6	19	14	14	0	27	27	20
DBA	21	21	7	36	7	29	14	14	7	29	0	62	7	50
SDS	20	40	20	20	0	40	20	0	20	20	0	60	20	40
Other	13	13	0	10	0	0	0	10	10	0	0	0	0	10
All non-DC patients*	26*	26*	9*	23*	7*	20*	9*	13*	12*	16*	0*	36*	14*	30*
Non-DC relatives	3	20	0	17	0	17	0	20	3	14	3	20	3	20

Diagnosis	Granulocytes		Lymphocytes		Naïve T cells		Memory T cells		B cells		NK/NKT cells		Leukocytes
Diagnosis	<1%	1-10%	<1%	1-10%	<1%	1-10%	<1%	1-10%	<1%	1-10%	<1%	1-10%	<1%	1-10%
DC patients*	96*	4*	92*	8*	96*	4*	85*	8*	92*	8*	72*	20*	100*	0*
DC relatives*	16*	22*	4*	15*	6*	13*	4*	13*	4*	15*	2*	10*	9*	39*
FA†	40	33	13	20	13	19	6	19	14	14	0	27	27	20
DBA	21	21	7	36	7	29	14	14	7	29	0	62	7	50
SDS	20	40	20	20	0	40	20	0	20	20	0	60	20	40
Other	13	13	0	10	0	0	0	10	10	0	0	0	0	10
All non-DC patients*	26*	26*	9*	23*	7*	20*	9*	13*	12*	16*	0*	36*	14*	30*
Non-DC relatives	3	20	0	17	0	17	0	20	3	14	3	20	3	20

Data are percentage of patients in the diagnostic group who had telomeres less than 1^st percentile (<1%), or between 1st and 10th percentile (1-10%). Telomeres that were normal or longer than normal (ie, 10th percentile or above) are not included.

The important groups for this study: DC patients, DC relatives, and all non-DC patients.

†

FA includes 1 patient after bone marrow transplant whose telomeres were normal, and 3 with hematopoietic somatic mosaicism.

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