Demographics and virologic and immunologic characteristics of the cohort
| Patient no. . | Age, y/sex . | Genotype . | HCV RNA, IU/mL . | CD4+ responses in short-term culture . | Risk factor . | Murex HCV serotype . | HCV proliferative response (SI >5) . |
|---|---|---|---|---|---|---|---|
| GT1 C1 | 48F | 1b | 300 000 | 1 | IDU | 1 | — |
| GT1 C2 | 43F | 1b | > 500 000 | 0 | IDU | 1 | — |
| GT1 C3 | 22F | 1a | 2 240 | 0 | IDU | 1 | — |
| GT1 C4 | 29F | 1a | > 500 000 | 0 | Unknown | ND | — |
| GT1 C5 | 31F | 1a | > 500 000 | 3 | IDU | 1 | — |
| GT1 C6 | 38M | 1a/1b | 450 000 | 0 | Transfusion | 1 | — |
| GT1 C7 | 40M | 1b | > 500 000 | 0 | Transfusion | 1 | — |
| GT1 C8 | 37M | 1a/1b | 420 000 | 0 | Transfusion | 1 | — |
| GT1 C9 | 59F | 1a | 39 600 | 0 | Transfusion | 1 | — |
| GT1 C10 | 47M | 1 | 100 000 | 0 | IDU | 1 | ND |
| GT1 C11 | 25M | 1 | > 500 000 | 1 | IDU | 1 | — |
| GT1 C12 | 64F | 1a | > 500 000 | 0 | Transfusion | 1 | — |
| GT1 C13 | 53M | 1 | > 500 000 | 0 | IDU | 1 | ND |
| GT1 C14 | 66F | 1 | 410 000 | 0 | Unknown | ND | ND |
| GT1 C15 | 21F | 1b | 160 000 | 0 | Transfusion | ND | — |
| GT1 C16 | 68M | 1a | > 500 000 | 0 | Transfusion | 1 | — |
| GT1 C17 | 37F | 1a | 330 000 | 0 | IDU | 1 | — |
| GT1 C18 | 49M | 1a | 420 000 | 0 | IDU | ND | — |
| GT1 C19 | 43M | 1a | > 500 000 | 0 | Multiple risk factors | 1 | — |
| GT1 C20 | 25M | 1a | > 500 000 | 0 | Unknown | ND | ND |
| GT1 C21 | 21M | 1a/1b | > 500 000 | 0 | IDU | 1 | ND |
| GT1 C22 | 56M | 1a | > 500 000 | 0 | IDU | 1 | ND |
| GT1 C23 | 75M | 1a | 474 000 | 0 | Transfusion | ND | — |
| GT1 C24 | 38M | 1a | > 500 000 | 0 | IDU | 1 | — |
| Non-GT1 C25 | 41F | 2a/2c | 38 600 | 2 | Needle stick | 2 | — |
| Non-GT1 C26 | 37F | 3a | 87 000 | 0 | IDU | ND | — |
| Non-GT1 C27 | 39M | 3a | > 500 000 | 0 | IDU | 3 | — |
| Non-GT1 C28 | 38M | 4c | 120 000 | 0 | Unknown | 4 | NS5 |
| Non-GT1 C29 | 45M | 4c | 230 000 | 5 | IDU | 1+4 | NS5 |
| Non-GT1 C30 | 47F | 4a/4b | > 500 000 | 1 | Unknown | 4 | NS4 |
| Non-GT1 C31 | 45F | 2 | 750 | 9 | Transfusion | 2 | — |
| Non-GT1 C32 | 49M | 2 | > 500 000 | 0 | IDU | 2 | — |
| Non-GT1 C33 | 27M | 3a | 100 000 | 0 | IDU | 3 | — |
| Non-GT1 C34 | 34M | 6a | 500 000 | 0 | Unknown | 6 | ND |
| Non-GT1 C35 | 50F | 2 | > 500 000 | 27 | IDU | 1+2 | NS4 + NS5 |
| Non-GT1 C36 | 52M | 3a | 57 000 | 12 | Unknown | 1+3 | — |
| Non-GT1 C37 | 47M | 3a | > 500 000 | 0 | IDU | 3 | — |
| Non-GT1 C38 | 43M | 3 | > 500 000 | 0 | Nosokomial | 3 | — |
| Non-GT1 C39 | 37M | 4 | > 500 000 | 0 | Sexual transmission | 4 | — |
| Non-GT1 C40 | 56F | 4a | 310 000 | 1 | IDU | 4 | — |
| Non-GT1 C41 | 57F | 3 | 396 000 | 16 | IDU | 2 | — |
| Non-GT1 C42 | 55M | 3a | 96 000 | 9 | IDU | 1 | NS4 + NS5 |
| Non-GT1 C43 | 50M | 2 | 500 000 | 6 | IDU | 2 | — |
| Non-GT1 C44 | 50M | 3a | 500 000 | 0 | IDU | 3 | NS4 |
| Patient no. . | Age, y/sex . | Genotype . | HCV RNA, IU/mL . | CD4+ responses in short-term culture . | Risk factor . | Murex HCV serotype . | HCV proliferative response (SI >5) . |
|---|---|---|---|---|---|---|---|
| GT1 C1 | 48F | 1b | 300 000 | 1 | IDU | 1 | — |
| GT1 C2 | 43F | 1b | > 500 000 | 0 | IDU | 1 | — |
| GT1 C3 | 22F | 1a | 2 240 | 0 | IDU | 1 | — |
| GT1 C4 | 29F | 1a | > 500 000 | 0 | Unknown | ND | — |
| GT1 C5 | 31F | 1a | > 500 000 | 3 | IDU | 1 | — |
| GT1 C6 | 38M | 1a/1b | 450 000 | 0 | Transfusion | 1 | — |
| GT1 C7 | 40M | 1b | > 500 000 | 0 | Transfusion | 1 | — |
| GT1 C8 | 37M | 1a/1b | 420 000 | 0 | Transfusion | 1 | — |
| GT1 C9 | 59F | 1a | 39 600 | 0 | Transfusion | 1 | — |
| GT1 C10 | 47M | 1 | 100 000 | 0 | IDU | 1 | ND |
| GT1 C11 | 25M | 1 | > 500 000 | 1 | IDU | 1 | — |
| GT1 C12 | 64F | 1a | > 500 000 | 0 | Transfusion | 1 | — |
| GT1 C13 | 53M | 1 | > 500 000 | 0 | IDU | 1 | ND |
| GT1 C14 | 66F | 1 | 410 000 | 0 | Unknown | ND | ND |
| GT1 C15 | 21F | 1b | 160 000 | 0 | Transfusion | ND | — |
| GT1 C16 | 68M | 1a | > 500 000 | 0 | Transfusion | 1 | — |
| GT1 C17 | 37F | 1a | 330 000 | 0 | IDU | 1 | — |
| GT1 C18 | 49M | 1a | 420 000 | 0 | IDU | ND | — |
| GT1 C19 | 43M | 1a | > 500 000 | 0 | Multiple risk factors | 1 | — |
| GT1 C20 | 25M | 1a | > 500 000 | 0 | Unknown | ND | ND |
| GT1 C21 | 21M | 1a/1b | > 500 000 | 0 | IDU | 1 | ND |
| GT1 C22 | 56M | 1a | > 500 000 | 0 | IDU | 1 | ND |
| GT1 C23 | 75M | 1a | 474 000 | 0 | Transfusion | ND | — |
| GT1 C24 | 38M | 1a | > 500 000 | 0 | IDU | 1 | — |
| Non-GT1 C25 | 41F | 2a/2c | 38 600 | 2 | Needle stick | 2 | — |
| Non-GT1 C26 | 37F | 3a | 87 000 | 0 | IDU | ND | — |
| Non-GT1 C27 | 39M | 3a | > 500 000 | 0 | IDU | 3 | — |
| Non-GT1 C28 | 38M | 4c | 120 000 | 0 | Unknown | 4 | NS5 |
| Non-GT1 C29 | 45M | 4c | 230 000 | 5 | IDU | 1+4 | NS5 |
| Non-GT1 C30 | 47F | 4a/4b | > 500 000 | 1 | Unknown | 4 | NS4 |
| Non-GT1 C31 | 45F | 2 | 750 | 9 | Transfusion | 2 | — |
| Non-GT1 C32 | 49M | 2 | > 500 000 | 0 | IDU | 2 | — |
| Non-GT1 C33 | 27M | 3a | 100 000 | 0 | IDU | 3 | — |
| Non-GT1 C34 | 34M | 6a | 500 000 | 0 | Unknown | 6 | ND |
| Non-GT1 C35 | 50F | 2 | > 500 000 | 27 | IDU | 1+2 | NS4 + NS5 |
| Non-GT1 C36 | 52M | 3a | 57 000 | 12 | Unknown | 1+3 | — |
| Non-GT1 C37 | 47M | 3a | > 500 000 | 0 | IDU | 3 | — |
| Non-GT1 C38 | 43M | 3 | > 500 000 | 0 | Nosokomial | 3 | — |
| Non-GT1 C39 | 37M | 4 | > 500 000 | 0 | Sexual transmission | 4 | — |
| Non-GT1 C40 | 56F | 4a | 310 000 | 1 | IDU | 4 | — |
| Non-GT1 C41 | 57F | 3 | 396 000 | 16 | IDU | 2 | — |
| Non-GT1 C42 | 55M | 3a | 96 000 | 9 | IDU | 1 | NS4 + NS5 |
| Non-GT1 C43 | 50M | 2 | 500 000 | 6 | IDU | 2 | — |
| Non-GT1 C44 | 50M | 3a | 500 000 | 0 | IDU | 3 | NS4 |
SI indicates stimulation index; —, no proliferation; and ND, not determined.