Pathologic analysis of insulitis in GM-CSF– and IL-3–deficient mice
| Genotype and islets scored . | Peri-insulitis . | Insulitis . | Necrosis . |
|---|---|---|---|
| Wild-type | |||
| 11 | 0 | 0 | 0 |
| 14 | 1 | 0 | 0 |
| 5 | 1 | 0 | 0 |
| 15 | 0 | 0 | 0 |
| 15 | 0 | 0 | 0 |
| GM-CSF−/− | |||
| 9 | 2 | 0 | 0 |
| 25 | 13 | 0 | 0 |
| 16 | 14 | 0 | 0 |
| 14 | 4 | 0 | 0 |
| 22 | 7 | 0 | 0 |
| 19 | 3 | 1 | 0 |
| 22 | 9 | 1 | 0 |
| IL-3−/− | |||
| 15 | 3 | 0 | 0 |
| 19 | 5 | 0 | 0 |
| 19 | 4 | 0 | 0 |
| 20 | 9 | 0 | 0 |
| GM-CSF/IL-3−/− | |||
| 19 | 0 | 8 | 0 |
| 17 | 4 | 4 | 0 |
| 5 | 1 | 4 | 0 |
| 11 | 3 | 4 | 0 |
| 11 | 4 | 7 | 1 |
| 18 | 2 | 13 | 1 |
| 6 | 2 | 4 | 2 |
| 17 | 7 | 8 | 6 |
| 14 | 7 | 7 | 6 |
| Genotype and islets scored . | Peri-insulitis . | Insulitis . | Necrosis . |
|---|---|---|---|
| Wild-type | |||
| 11 | 0 | 0 | 0 |
| 14 | 1 | 0 | 0 |
| 5 | 1 | 0 | 0 |
| 15 | 0 | 0 | 0 |
| 15 | 0 | 0 | 0 |
| GM-CSF−/− | |||
| 9 | 2 | 0 | 0 |
| 25 | 13 | 0 | 0 |
| 16 | 14 | 0 | 0 |
| 14 | 4 | 0 | 0 |
| 22 | 7 | 0 | 0 |
| 19 | 3 | 1 | 0 |
| 22 | 9 | 1 | 0 |
| IL-3−/− | |||
| 15 | 3 | 0 | 0 |
| 19 | 5 | 0 | 0 |
| 19 | 4 | 0 | 0 |
| 20 | 9 | 0 | 0 |
| GM-CSF/IL-3−/− | |||
| 19 | 0 | 8 | 0 |
| 17 | 4 | 4 | 0 |
| 5 | 1 | 4 | 0 |
| 11 | 3 | 4 | 0 |
| 11 | 4 | 7 | 1 |
| 18 | 2 | 13 | 1 |
| 6 | 2 | 4 | 2 |
| 17 | 7 | 8 | 6 |
| 14 | 7 | 7 | 6 |
GM-CSF indicates granulocyte-macrophage colony-stimulating factor; IL-3, interleukin 3.