Genes up-regulated in the absence of EKLF
| Gene symbols . | Gene name . | Ratio of WT to KO (P) . |
|---|---|---|
| ITGA2B | Integrin α 2b | 0.4 (<.001) |
| VWF | Von Willebrand factor homolog | 0.3 (<.001) |
| FLI1 | Friend leukemia integration 1 | 0.4 (.004) |
| PF4 (CXCL4) | Platelet factor 4 | 0.5 (.006) |
| THBS1 | Thrombospondin 1 | 0.3 (.001) |
| PECAM | Platelet/endothelial cell adhesion molecule | 0.4 (.007) |
| Gene symbols . | Gene name . | Ratio of WT to KO (P) . |
|---|---|---|
| ITGA2B | Integrin α 2b | 0.4 (<.001) |
| VWF | Von Willebrand factor homolog | 0.3 (<.001) |
| FLI1 | Friend leukemia integration 1 | 0.4 (.004) |
| PF4 (CXCL4) | Platelet factor 4 | 0.5 (.006) |
| THBS1 | Thrombospondin 1 | 0.3 (.001) |
| PECAM | Platelet/endothelial cell adhesion molecule | 0.4 (.007) |
High-density oligonucleotide microarrays (Affymetrix, Santa Clara, CA) were analyzed with RNA from wild-type (WT) and EKLF-null (KO) E13.5 fetal livers (M. Arcosoy and P.G.G., manuscript in preparation). Three independent RNA samples were analyzed. Expression levels of genes relevant to megakaryocyte expression are shown as a ratio between WT and KO levels, along with their P value. Relevant genes that were not affected include c-mpl, PBP (CXCL7), RANTES (CCL5), and ENA78 (CXCL5).