Genes (including hypothetical genes/proteins and open reading frames [ORFs]) differentially expressed 2-fold or greater among the identified BAALC-associated gene-expression signature
| Gene symbol . | Description . | Fold change . |
|---|---|---|
| Genes overexpressed in the high BAALC group | ||
| PROM1 | Prominin 1, CD133 | 7.1 |
| BAALC* | Brain and acute leukemia, cytoplasmic | 4.8 |
| ITM2A* | Integral membrane protein 2A | 3.6 |
| HGF | Hepatocyte growth factor (hepapoietin A; scatter factor) | 3.4 |
| CD34 | CD34 molecule | 3.4 |
| UMODL1 | Uromodulin-like 1 | 3.3 |
| MN1 | Meningioma (disrupted in balanced translocation) 1 | 3.1 |
| C5orf23 | Chromosome 5 open reading frame 23 | 3.1 |
| C1QTNF4 | C1q and tumor necrosis factor related protein 4 | 2.9 |
| GPR174 | G protein–coupled receptor 174 | 2.9 |
| NPR3* | Natriuretic peptide receptor C/guanylate cyclase C | 2.8 |
| FLJ10489 | Hypothetical protein FLJ10489 | 2.8 |
| FZD6 | Frizzled homolog 6 (Drosophila) | 2.7 |
| ABCB1 | ATP-binding cassette, sub–family B (MDR/TAP), member 1, MDR1 | 2.7 |
| JUP | Junction plakoglobin | 2.7 |
| KIT | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog | 2.6 |
| RP1-93H18.5* | Hypothetical protein LOC441168 | 2.6 |
| TSPAN13 | Tetraspanin 13 | 2.6 |
| B4GALT6* | UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 6 | 2.5 |
| SORL1 | Sortilin-related receptor, L(DLR class) A repeats-containing | 2.4 |
| BRDG1 | BCR downstream signaling 1 | 2.3 |
| HLA-DOA | Major histocompatibility complex, class II, DO alpha | 2.2 |
| S100Z | S100 calcium binding protein Z | 2.1 |
| CRYGD | Crystallin, gamma D | 2.1 |
| CD200* | CD200 molecule | 2.1 |
| PLAGL1* | Pleiomorphic adenoma gene-like 1 | 2.1 |
| ITM2C | Integral membrane protein 2C | 2.1 |
| RP11-50D16.3 | Similar to RIKEN cDNA 8030451K01 | 2.0 |
| TRAF5 | TNF receptor–associated factor 5 | 2.0 |
| Genes underexpressed in the high BAALCgroup | ||
| CT45*† | Cancer/testis antigen CT45 | 11.6 |
| GAS2L3 | Growth arrest–specific 2 like 3 | 3.5 |
| SUCLG2* | Succinate-CoA ligase, GDP-forming, beta subunit | 3.2 |
| SLC22A15 | Solute carrier family 22 (organic cation transporter), member 15 | 3.1 |
| HOXB6 | Homeobox B6 | 3.0 |
| TUBB6 | Tubulin, beta 6 | 2.8 |
| HNRPLL* | Heterogeneous nuclear ribonucleoprotein L-like | 2.8 |
| IRX5 | Iroquois homeobox protein 5 | 2.6 |
| FAM127A | Family with sequence similarity 127, member A | 2.6 |
| HIST1H2BG‡ | Histone cluster 1, H2bg | 2.5 |
| C5orf32 | Chromosome 5 open reading frame 32 | 2.4 |
| C3AR1 | Complement component 3a receptor 1 | 2.4 |
| CAST* | Calpastatin | 2.2 |
| PLAUR* | Plasminogen activator, urokinase receptor | 2.1 |
| HIST2H2AA3§ | Histone cluster 2, H2aa3 | 2.1 |
| HOXB7* | Homeobox B7 | 2.1 |
| ANXA2* | Annexin A2 | 2.1 |
| ELL2* | Elongation factor, RNA polymerase II, 2 | 2.1 |
| MGC26963 | Hypothetical protein MGC26963 | 2.0 |
| Gene symbol . | Description . | Fold change . |
|---|---|---|
| Genes overexpressed in the high BAALC group | ||
| PROM1 | Prominin 1, CD133 | 7.1 |
| BAALC* | Brain and acute leukemia, cytoplasmic | 4.8 |
| ITM2A* | Integral membrane protein 2A | 3.6 |
| HGF | Hepatocyte growth factor (hepapoietin A; scatter factor) | 3.4 |
| CD34 | CD34 molecule | 3.4 |
| UMODL1 | Uromodulin-like 1 | 3.3 |
| MN1 | Meningioma (disrupted in balanced translocation) 1 | 3.1 |
| C5orf23 | Chromosome 5 open reading frame 23 | 3.1 |
| C1QTNF4 | C1q and tumor necrosis factor related protein 4 | 2.9 |
| GPR174 | G protein–coupled receptor 174 | 2.9 |
| NPR3* | Natriuretic peptide receptor C/guanylate cyclase C | 2.8 |
| FLJ10489 | Hypothetical protein FLJ10489 | 2.8 |
| FZD6 | Frizzled homolog 6 (Drosophila) | 2.7 |
| ABCB1 | ATP-binding cassette, sub–family B (MDR/TAP), member 1, MDR1 | 2.7 |
| JUP | Junction plakoglobin | 2.7 |
| KIT | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog | 2.6 |
| RP1-93H18.5* | Hypothetical protein LOC441168 | 2.6 |
| TSPAN13 | Tetraspanin 13 | 2.6 |
| B4GALT6* | UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 6 | 2.5 |
| SORL1 | Sortilin-related receptor, L(DLR class) A repeats-containing | 2.4 |
| BRDG1 | BCR downstream signaling 1 | 2.3 |
| HLA-DOA | Major histocompatibility complex, class II, DO alpha | 2.2 |
| S100Z | S100 calcium binding protein Z | 2.1 |
| CRYGD | Crystallin, gamma D | 2.1 |
| CD200* | CD200 molecule | 2.1 |
| PLAGL1* | Pleiomorphic adenoma gene-like 1 | 2.1 |
| ITM2C | Integral membrane protein 2C | 2.1 |
| RP11-50D16.3 | Similar to RIKEN cDNA 8030451K01 | 2.0 |
| TRAF5 | TNF receptor–associated factor 5 | 2.0 |
| Genes underexpressed in the high BAALCgroup | ||
| CT45*† | Cancer/testis antigen CT45 | 11.6 |
| GAS2L3 | Growth arrest–specific 2 like 3 | 3.5 |
| SUCLG2* | Succinate-CoA ligase, GDP-forming, beta subunit | 3.2 |
| SLC22A15 | Solute carrier family 22 (organic cation transporter), member 15 | 3.1 |
| HOXB6 | Homeobox B6 | 3.0 |
| TUBB6 | Tubulin, beta 6 | 2.8 |
| HNRPLL* | Heterogeneous nuclear ribonucleoprotein L-like | 2.8 |
| IRX5 | Iroquois homeobox protein 5 | 2.6 |
| FAM127A | Family with sequence similarity 127, member A | 2.6 |
| HIST1H2BG‡ | Histone cluster 1, H2bg | 2.5 |
| C5orf32 | Chromosome 5 open reading frame 32 | 2.4 |
| C3AR1 | Complement component 3a receptor 1 | 2.4 |
| CAST* | Calpastatin | 2.2 |
| PLAUR* | Plasminogen activator, urokinase receptor | 2.1 |
| HIST2H2AA3§ | Histone cluster 2, H2aa3 | 2.1 |
| HOXB7* | Homeobox B7 | 2.1 |
| ANXA2* | Annexin A2 | 2.1 |
| ELL2* | Elongation factor, RNA polymerase II, 2 | 2.1 |
| MGC26963 | Hypothetical protein MGC26963 | 2.0 |
The gene was represented by multiple probe sets in the identified signature. The displayed fold change is the geometric mean of all the probe sets in the signature representing the gene.
Affymetrix probe sets 235700_at and 1567912_s_at recognize 6 nearly identical copies of the CT45 gene, CT45-1 through CT45-6.50 The probe sets do not discriminate among these 6 genes.
Affymetrix probe set 214455_at recognizes HIST1H2BG and also recognizes HIST1H2BC. The probe set does not discriminate between HIST1H2BG and HIST1H2BC.
Affymetrix probe set 218280_x_at recognizes HIST2H2AA3 and also recognizes HIST2H2AA4. The probe set does not discriminate between HIST2H2AA3 and HIST2H2AA4.