Apoptosis-related genes either up- or down-regulated (I or D calls) in all 4 cell lines obtained using Affymetrix microarray following ATO treatment
| Gene descriptor . | Symbol . | U266 . | MM.1s . | 8226/S . | KMS11 . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 6 h . | 24 h . | 48 h . | 6 h . | 24 h . | 48 h . | 6 h . | 24 h . | 48 h . | 6 h . | 24 h . | 48 h . | ||
| B-cell CLL/lymphoma 2 | BCL2 | 1.3 | 1.4 | 1.7 | 1.0 | 1.2 | 1.5 | 1.3 | 1.2 | 1.6 | 1.2 | 1.2 | 1.5 |
| Caspase 8, apoptosis-related cysteine protease | CASP8 | 1.0 | 1.3 | 1.5 | 1.6 | 1.4 | 1.4 | 1.5 | 1.1 | 1.3 | 2.1 | 1.8 | 1.6 |
| Fas (TNFRSF6)-associated via death domain | FADD | 1.5 | 1.3 | 1.6 | 1.6 | 1.0 | 1.4 | 1.3 | 1.1 | 1.1 | 1.4 | −1.2 | −1.1 |
| TNF receptor superfamily, member 6 (Fas/CD95) | TNFRSF6 | 1.1 | 1.5 | 1.4 | 4.6 | 3.7 | 2.6 | 1.1 | 1.1 | 1.5 | 1.0 | 1.7 | 1.4 |
| Baculoviral IAP repeat-containing 5 (survivin) | BIRC5 | −1.4 | −1.4 | −2.2 | −1.4 | −1.3 | −3.8 | −1.0 | −1.1 | −1.3 | −1.5 | 1.1 | −1.2 |
| BCL2-like 1 | BCL2L1 | −2.2 | −2.5 | −2.1 | −1.6 | −2.0 | −3.2 | −1.4 | −1.5 | −1.5 | −2.7 | −2.7 | −2.9 |
| Gene descriptor . | Symbol . | U266 . | MM.1s . | 8226/S . | KMS11 . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 6 h . | 24 h . | 48 h . | 6 h . | 24 h . | 48 h . | 6 h . | 24 h . | 48 h . | 6 h . | 24 h . | 48 h . | ||
| B-cell CLL/lymphoma 2 | BCL2 | 1.3 | 1.4 | 1.7 | 1.0 | 1.2 | 1.5 | 1.3 | 1.2 | 1.6 | 1.2 | 1.2 | 1.5 |
| Caspase 8, apoptosis-related cysteine protease | CASP8 | 1.0 | 1.3 | 1.5 | 1.6 | 1.4 | 1.4 | 1.5 | 1.1 | 1.3 | 2.1 | 1.8 | 1.6 |
| Fas (TNFRSF6)-associated via death domain | FADD | 1.5 | 1.3 | 1.6 | 1.6 | 1.0 | 1.4 | 1.3 | 1.1 | 1.1 | 1.4 | −1.2 | −1.1 |
| TNF receptor superfamily, member 6 (Fas/CD95) | TNFRSF6 | 1.1 | 1.5 | 1.4 | 4.6 | 3.7 | 2.6 | 1.1 | 1.1 | 1.5 | 1.0 | 1.7 | 1.4 |
| Baculoviral IAP repeat-containing 5 (survivin) | BIRC5 | −1.4 | −1.4 | −2.2 | −1.4 | −1.3 | −3.8 | −1.0 | −1.1 | −1.3 | −1.5 | 1.1 | −1.2 |
| BCL2-like 1 | BCL2L1 | −2.2 | −2.5 | −2.1 | −1.6 | −2.0 | −3.2 | −1.4 | −1.5 | −1.5 | −2.7 | −2.7 | −2.9 |
Ratios versus baseline expression are shown. Positive values indicate up-regulation, while negative values indicate down-regulation. Two-fold changes are in bold.