Table 1 HLA-G functions Effector cell,... | American Society of Hematology

Table 1

HLA-G functions

Effector cell, HLA-G function	Receptors involved	Reference
NK cells
Inhibition of cytotoxic function	ILT2, KIR2DL4	32, 33
Indirect inhibition of cytotoxic function through stabilization of cell-surface HLA-E	CD94/NKG2A (interacts w/HLA-E)	86
Inhibition of proliferation	ILT2	39
Up-regulation of inhibitory receptors	—	87
Apoptosis	CD8	88, 89
Increased proliferation and IFNγ production	KIR2DL4	46, 90
Increased secretion of pro-angiogenic factors	Internalized KIR2DL4	47
Inhibition of transendothelial migration	ILT2	91
CD8⁺T cells
Inhibition of cytotoxic function	—	34, 92
Inhibition of proliferation	ILT2	37
Generation of CD8^low regulatory T cells	—	55
Apoptosis	CD8	89
CD4⁺T cells
Inhibition of alloreactivity	ILT2, ILT4⁵⁷	35, 82
Inhibition of proliferation	ILT2	37, 38
Up-regulation of inhibitory receptors	—	87
Generation of regulatory T cells, which include CD4^low T cells	—	55, 82
APC
Inhibition of DC maturation, antigen presentation, trafficking, and induction of regulatory T cells	ILT4	40
Up-regulation of inhibitory receptors	—	87
PBMC: secretion of Th2 cytokines	CD160	93
Endothelial cells: apoptosis	—	94

Effector cell, HLA-G function	Receptors involved	Reference
NK cells
Inhibition of cytotoxic function	ILT2, KIR2DL4	32, 33
Indirect inhibition of cytotoxic function through stabilization of cell-surface HLA-E	CD94/NKG2A (interacts w/HLA-E)	86
Inhibition of proliferation	ILT2	39
Up-regulation of inhibitory receptors	—	87
Apoptosis	CD8	88, 89
Increased proliferation and IFNγ production	KIR2DL4	46, 90
Increased secretion of pro-angiogenic factors	Internalized KIR2DL4	47
Inhibition of transendothelial migration	ILT2	91
CD8⁺T cells
Inhibition of cytotoxic function	—	34, 92
Inhibition of proliferation	ILT2	37
Generation of CD8^low regulatory T cells	—	55
Apoptosis	CD8	89
CD4⁺T cells
Inhibition of alloreactivity	ILT2, ILT4⁵⁷	35, 82
Inhibition of proliferation	ILT2	37, 38
Up-regulation of inhibitory receptors	—	87
Generation of regulatory T cells, which include CD4^low T cells	—	55, 82
APC
Inhibition of DC maturation, antigen presentation, trafficking, and induction of regulatory T cells	ILT4	40
Up-regulation of inhibitory receptors	—	87
PBMC: secretion of Th2 cytokines	CD160	93
Endothelial cells: apoptosis	—	94

— indicates not available.