Clinical and laboratory findings at diagnosis and during the course of the disease
| . | Total (n = 146) . | Early death (n = 22) . | AML (n = 29) . | Cytarabine (n = 28) . |
|---|---|---|---|---|
| Median birth weight, kg (range)* | 2.9 (1.3-5.6) | 2.6 (1.3-4.2) | 2.8 (2-3.8) | 2.8 (1.3-5.6) |
| Median birth length, cm (range)† | 48.0 (34-66) | 46.5 (36-53) | 49.0 (41-66) | 48.5 (36-56) |
| Median gestational age, wk (range)‡ | 37.0 (30-41) | 35.0 (30-40) | 38.0 (34-40) | 36.0 (30-40) |
| Median WBC count, × 109/L (range)§ | 40.3 (3.9-556) | 74 (6-410) | 42.1 (5.1-131) | 62.4 (5.5-556) |
| Median platelets, × 109/L§ | 119 (4-1047) | 149 (30-717) | 81 (22-1047) | 135 (20-1047) |
| Median hemoglobin, g/L (range)§ | 14.5 (4.8-25.7) | 13.8 (9.2-18.7) | 14.3 (8.4-20.4) | 13.7 (6.7-21.7) |
| Median blasts PB, % (range)§ | 39 (2-95) | 37 (3-95) | 32.5 (9-81) | 38 (4-95) |
| Median blasts BM, % (range)* | 32 (5-93) | 18 (5-45) | 15 (10-67) | 17 (265-54) |
| Elevated AST, % (no.)‖ | 28 (27) | 29 (5) | 27 (4) | 48 (12) |
| Elevated ALT, % (no.)‖ | 24 (23) | 35 (6) | 27 (4) | 52 (13) |
| Pathologic coagulation, % (no.)* | 22 (23) | 45 (9) | 18 (3) | 42 (11) |
| Hydrops fetalis, % (no.)¶ | 5 (7) | 23 (5) | 3 (1) | 18 (5) |
| Pleural effusion, % (no.) ¶ | 16 (24) | 23 (5) | 31 (9) | 29 (8) |
| Pericardial effusion, % (no.) ¶ | 12 (17) | 14 (3) | 21 (6) | 21 (6) |
| Ascites, % (no.) ¶ | 8 (12) | 32 (7) | 10 (3) | 14 (4) |
| Splenomegaly, % (no.)* | 42 (44) | 53 (10) | 53 (9) | 62 (16) |
| Hepatomegaly, % (no.)* | 60 (62) | 68 (13) | 65 (11) | 73 (19) |
| Cholestasis, % (no.)* | 15 (16) | 37 (7) | 12 (2) | 23 (6) |
| Liver fibrosis, % (no.)* | 7 (7) | 35 (7) | 0 (0) | 12 (3) |
| Liver dysfunction, % (no.) ‡ | 41 (32) | 65 (11) | 54 (7) | 63 (10) |
| Renal failure, % (no.)* | 6 (6) | 32 (6) | 0 (0) | 8 (2) |
| Bleeding diatheses, % (no.)* | 9 (9) | 32 (6) | 0 (0) | 23 (6) |
| Intensive care, % (no.) ¶ | 25 (37) | 68 (15) | 21 (6) | 46 (13) |
| Ventilation required, % (no.)* | 29 (30) | 74 (14) | 24 (4) | 42 (11) |
| Therapy applied, % (no.) ¶ | 19 (28) | 32 (7) | 21 (6) | 100 (28) |
| Cardiac defects, % (no.) ¶ | 47 (68) | 59 (13) | 45 (13) | 50 (14) |
| Intestinal stenosis, % (no.)* | 1 (1) | 5 (1) | 0 (0) | 4 (1) |
| Free trisomy, % (no.)* | 66 (69) | 80 (16) | 59 (10) | 77 (20) |
| Mosaicism, % (no.)* | 7 (7) | 5 (1) | 6 (1) | 0 (0) |
| Translocation, % (no.)* | 2 (2) | 0 (0) | 6 (1) | 0 (0) |
| . | Total (n = 146) . | Early death (n = 22) . | AML (n = 29) . | Cytarabine (n = 28) . |
|---|---|---|---|---|
| Median birth weight, kg (range)* | 2.9 (1.3-5.6) | 2.6 (1.3-4.2) | 2.8 (2-3.8) | 2.8 (1.3-5.6) |
| Median birth length, cm (range)† | 48.0 (34-66) | 46.5 (36-53) | 49.0 (41-66) | 48.5 (36-56) |
| Median gestational age, wk (range)‡ | 37.0 (30-41) | 35.0 (30-40) | 38.0 (34-40) | 36.0 (30-40) |
| Median WBC count, × 109/L (range)§ | 40.3 (3.9-556) | 74 (6-410) | 42.1 (5.1-131) | 62.4 (5.5-556) |
| Median platelets, × 109/L§ | 119 (4-1047) | 149 (30-717) | 81 (22-1047) | 135 (20-1047) |
| Median hemoglobin, g/L (range)§ | 14.5 (4.8-25.7) | 13.8 (9.2-18.7) | 14.3 (8.4-20.4) | 13.7 (6.7-21.7) |
| Median blasts PB, % (range)§ | 39 (2-95) | 37 (3-95) | 32.5 (9-81) | 38 (4-95) |
| Median blasts BM, % (range)* | 32 (5-93) | 18 (5-45) | 15 (10-67) | 17 (265-54) |
| Elevated AST, % (no.)‖ | 28 (27) | 29 (5) | 27 (4) | 48 (12) |
| Elevated ALT, % (no.)‖ | 24 (23) | 35 (6) | 27 (4) | 52 (13) |
| Pathologic coagulation, % (no.)* | 22 (23) | 45 (9) | 18 (3) | 42 (11) |
| Hydrops fetalis, % (no.)¶ | 5 (7) | 23 (5) | 3 (1) | 18 (5) |
| Pleural effusion, % (no.) ¶ | 16 (24) | 23 (5) | 31 (9) | 29 (8) |
| Pericardial effusion, % (no.) ¶ | 12 (17) | 14 (3) | 21 (6) | 21 (6) |
| Ascites, % (no.) ¶ | 8 (12) | 32 (7) | 10 (3) | 14 (4) |
| Splenomegaly, % (no.)* | 42 (44) | 53 (10) | 53 (9) | 62 (16) |
| Hepatomegaly, % (no.)* | 60 (62) | 68 (13) | 65 (11) | 73 (19) |
| Cholestasis, % (no.)* | 15 (16) | 37 (7) | 12 (2) | 23 (6) |
| Liver fibrosis, % (no.)* | 7 (7) | 35 (7) | 0 (0) | 12 (3) |
| Liver dysfunction, % (no.) ‡ | 41 (32) | 65 (11) | 54 (7) | 63 (10) |
| Renal failure, % (no.)* | 6 (6) | 32 (6) | 0 (0) | 8 (2) |
| Bleeding diatheses, % (no.)* | 9 (9) | 32 (6) | 0 (0) | 23 (6) |
| Intensive care, % (no.) ¶ | 25 (37) | 68 (15) | 21 (6) | 46 (13) |
| Ventilation required, % (no.)* | 29 (30) | 74 (14) | 24 (4) | 42 (11) |
| Therapy applied, % (no.) ¶ | 19 (28) | 32 (7) | 21 (6) | 100 (28) |
| Cardiac defects, % (no.) ¶ | 47 (68) | 59 (13) | 45 (13) | 50 (14) |
| Intestinal stenosis, % (no.)* | 1 (1) | 5 (1) | 0 (0) | 4 (1) |
| Free trisomy, % (no.)* | 66 (69) | 80 (16) | 59 (10) | 77 (20) |
| Mosaicism, % (no.)* | 7 (7) | 5 (1) | 6 (1) | 0 (0) |
| Translocation, % (no.)* | 2 (2) | 0 (0) | 6 (1) | 0 (0) |