Table 1 Rate constants of proteolysis at... | American Society of Hematology

Table 1

Rate constants of proteolysis at R⁵⁰⁶ and R³⁰⁶ in plasma factor Va by APC

	n	k₅₀₆, mol⁻¹ sec⁻¹	Fold-stimulation	k₃₀₆, mol⁻¹ sec⁻¹	Fold-stimulation
Normal factor Va
APC	3	8.03 ± 1.50 × 10⁷	—	3.77 ± 1.27 × 10⁶	—
APC plus protein S	4	6.56 ± 0.44 × 10⁷	0.82	6.76 ± 0.25 × 10⁷	18
APC plus protein S-C4BP	4	2.31 ± 0.89 × 10⁷	0.29	4.25 ± 0.58 × 10⁷	11
Factor Va_Leiden
APC	6	—	—	2.79 ± 1.04 × 10⁶	—
APC plus protein S	6	—	—	7.38 ± 2.94 × 10⁷	26
APC plus protein S-C4BP	6	—	—	3.62 ± 1.13 × 10⁷	13

	n	k₅₀₆, mol⁻¹ sec⁻¹	Fold-stimulation	k₃₀₆, mol⁻¹ sec⁻¹	Fold-stimulation
Normal factor Va
APC	3	8.03 ± 1.50 × 10⁷	—	3.77 ± 1.27 × 10⁶	—
APC plus protein S	4	6.56 ± 0.44 × 10⁷	0.82	6.76 ± 0.25 × 10⁷	18
APC plus protein S-C4BP	4	2.31 ± 0.89 × 10⁷	0.29	4.25 ± 0.58 × 10⁷	11
Factor Va_Leiden
APC	6	—	—	2.79 ± 1.04 × 10⁶	—
APC plus protein S	6	—	—	7.38 ± 2.94 × 10⁷	26
APC plus protein S-C4BP	6	—	—	3.62 ± 1.13 × 10⁷	13

Concentrations of protein S and protein S-C4BP were 200 nM. Rate constants were determined as described.¹⁶ Data are presented as means plus or minus SD.

— indicates not applicable.

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