List of candidate genes examined
| Gene function . | Gene . | Chromosomal location . | No. SNPs examined . |
|---|---|---|---|
| Adhesion | Vascular cell adhesion molecule 1 (VCAM1) | 1p32-p31 | 1 |
| Complement receptor 1 (CR1) | 1q32 | 8 | |
| P-selectin (SELP) | 1q23-q25 | 9 | |
| Alpha V integrin (ITGAV) | 2q31 | 7 | |
| CD47 antigen (CD47) | 3q13.1-q13.2 | 4 | |
| CD36 antigen (CD36) | 7q11.2 | 7 | |
| Signal Transduction | Protein kinase, cAMP-dependent, catalytic, beta (PRKACB) | 1p36.1 | 6 |
| Angiotensinogen (AGT) | 1q42-q43 | 5 | |
| Beta 2 adrenergic receptor (ADRB2) | 5q32-q34 | 4 | |
| Protein kinase, cAMP-dependent, regulatory, type II, beta (PRKAR2B) | 7q22 | 6 | |
| Cyclin dependent kinase 5 (CDK5) | 7q36 | 1 | |
| Beta 1 adrenergic receptor (ADRB1) | 10q24-q26 | 5 | |
| Adenylate cyclase 6 (ADCY6) | 12q12-q13 | 6 | |
| Protein kinase C beta 1 (PRKCB1) | 16p11.2 | 4 | |
| Lipopolysaccharide-induced tumor necrosis factor alpha factor (LITAF) | 16p21.3 | 6 | |
| Angiotensin-converting enzyme (ACE) | 17q23 | 3 | |
| Phosphodiesterase 4C (PDE4C) | 19p13.1 | 1 | |
| Phosphodiesterase 4A (PDE4A) | 19p13.2 | 1 | |
| Coagulation | Factor XIII subunit B (F13B) | 1q31-q32.1 | 1 |
| Antithrombin III (SERPINC1) | 1q23-q25 | 2 | |
| Factor V (F5) | 1q23 | 12 | |
| Factor XIII subunit A1 (F13A1) | 6p25-p24 | 13 | |
| Factor II (F2) | 11p11-q12 | 2 | |
| NO biology | Nitric oxide synthase 3 (NOS3, endothelial) | 7q36 | 8 |
| Klotho (KL) | 13q12 | 24 | |
| Arginase, type II (ARG2) | 14q24.1-q24.3 | 5 | |
| Nitric oxide synthase 2A (NOS2A, inducible) | 17cen-q11.2 | 10 | |
| Heme oxygenase 1 (HMOX1) | 22q12 | 2 | |
| TGFβ superfamily | Transforming growth factor beta receptor III (TGFBR3) | 1p33-p32 | 20 |
| Bone morphogenic protein receptor type 2 (BMPR2) | 2q33 | 6 | |
| Transforming growth factor beta receptor II (TGFBR2) | 3p22 | 17 | |
| Bone morphogenic protein 6 (BMP6) | 6p24-p23 | 19 | |
| Activin receptor-like kinase 1 (ACVRL1) | 12q11-q14 | 5 | |
| Transporters and ion channels | Aquaporin 1 (AQP1) | 7p14 | 3 |
| Band 3–like protein (SLC4A2/BND3L) | 7q35-q36 | 1 | |
| Solute carrier family 12 (potassium/chloride transporters), member 6 (SLC12A6) | 15q13 | 4 | |
| Solute carrier family 12 member 4 (SLC12A4) | 16q22.1 | 2 | |
| Potassium voltage-gated channel, subfamily H (KCNH6) | 17q23 | 1 | |
| Solute carrier family 12, (potassium-chloride transporter) member 5 (SLC12A5) | 20q12-q13.1 | 1 | |
| Cytokine receptors | Duffy blood group (FY) | 1q21-q22 | 2 |
| Interleukin-4 receptor (IL4R) | 16p12.1-p11.2 | 18 | |
| Other | Component of oligomeric golgi complex 2 (COG2) | 1q | 3 |
| Developmentally regulated RNA-binding protein 1 (DRB1) | 2q31 | 2 | |
| Leukotriene A4 hydrolase (LTA4H) | 12q22 | 4 | |
| Annexin A2 (ANXA2) | 15q21-q22 | 15 | |
| Lecithin cholesterol acetyltransferase (LCAT) | 16q22.1 | 3 | |
| Nuclear receptor coactivator 5 (NCOA5) | 20 | 2 | |
| GNAS complex locus (GNAS) | 20q13.2 | 5 | |
| Splicing factor, arginine/serine-rich 15 (SFRS15) | 21 | 1 |
| Gene function . | Gene . | Chromosomal location . | No. SNPs examined . |
|---|---|---|---|
| Adhesion | Vascular cell adhesion molecule 1 (VCAM1) | 1p32-p31 | 1 |
| Complement receptor 1 (CR1) | 1q32 | 8 | |
| P-selectin (SELP) | 1q23-q25 | 9 | |
| Alpha V integrin (ITGAV) | 2q31 | 7 | |
| CD47 antigen (CD47) | 3q13.1-q13.2 | 4 | |
| CD36 antigen (CD36) | 7q11.2 | 7 | |
| Signal Transduction | Protein kinase, cAMP-dependent, catalytic, beta (PRKACB) | 1p36.1 | 6 |
| Angiotensinogen (AGT) | 1q42-q43 | 5 | |
| Beta 2 adrenergic receptor (ADRB2) | 5q32-q34 | 4 | |
| Protein kinase, cAMP-dependent, regulatory, type II, beta (PRKAR2B) | 7q22 | 6 | |
| Cyclin dependent kinase 5 (CDK5) | 7q36 | 1 | |
| Beta 1 adrenergic receptor (ADRB1) | 10q24-q26 | 5 | |
| Adenylate cyclase 6 (ADCY6) | 12q12-q13 | 6 | |
| Protein kinase C beta 1 (PRKCB1) | 16p11.2 | 4 | |
| Lipopolysaccharide-induced tumor necrosis factor alpha factor (LITAF) | 16p21.3 | 6 | |
| Angiotensin-converting enzyme (ACE) | 17q23 | 3 | |
| Phosphodiesterase 4C (PDE4C) | 19p13.1 | 1 | |
| Phosphodiesterase 4A (PDE4A) | 19p13.2 | 1 | |
| Coagulation | Factor XIII subunit B (F13B) | 1q31-q32.1 | 1 |
| Antithrombin III (SERPINC1) | 1q23-q25 | 2 | |
| Factor V (F5) | 1q23 | 12 | |
| Factor XIII subunit A1 (F13A1) | 6p25-p24 | 13 | |
| Factor II (F2) | 11p11-q12 | 2 | |
| NO biology | Nitric oxide synthase 3 (NOS3, endothelial) | 7q36 | 8 |
| Klotho (KL) | 13q12 | 24 | |
| Arginase, type II (ARG2) | 14q24.1-q24.3 | 5 | |
| Nitric oxide synthase 2A (NOS2A, inducible) | 17cen-q11.2 | 10 | |
| Heme oxygenase 1 (HMOX1) | 22q12 | 2 | |
| TGFβ superfamily | Transforming growth factor beta receptor III (TGFBR3) | 1p33-p32 | 20 |
| Bone morphogenic protein receptor type 2 (BMPR2) | 2q33 | 6 | |
| Transforming growth factor beta receptor II (TGFBR2) | 3p22 | 17 | |
| Bone morphogenic protein 6 (BMP6) | 6p24-p23 | 19 | |
| Activin receptor-like kinase 1 (ACVRL1) | 12q11-q14 | 5 | |
| Transporters and ion channels | Aquaporin 1 (AQP1) | 7p14 | 3 |
| Band 3–like protein (SLC4A2/BND3L) | 7q35-q36 | 1 | |
| Solute carrier family 12 (potassium/chloride transporters), member 6 (SLC12A6) | 15q13 | 4 | |
| Solute carrier family 12 member 4 (SLC12A4) | 16q22.1 | 2 | |
| Potassium voltage-gated channel, subfamily H (KCNH6) | 17q23 | 1 | |
| Solute carrier family 12, (potassium-chloride transporter) member 5 (SLC12A5) | 20q12-q13.1 | 1 | |
| Cytokine receptors | Duffy blood group (FY) | 1q21-q22 | 2 |
| Interleukin-4 receptor (IL4R) | 16p12.1-p11.2 | 18 | |
| Other | Component of oligomeric golgi complex 2 (COG2) | 1q | 3 |
| Developmentally regulated RNA-binding protein 1 (DRB1) | 2q31 | 2 | |
| Leukotriene A4 hydrolase (LTA4H) | 12q22 | 4 | |
| Annexin A2 (ANXA2) | 15q21-q22 | 15 | |
| Lecithin cholesterol acetyltransferase (LCAT) | 16q22.1 | 3 | |
| Nuclear receptor coactivator 5 (NCOA5) | 20 | 2 | |
| GNAS complex locus (GNAS) | 20q13.2 | 5 | |
| Splicing factor, arginine/serine-rich 15 (SFRS15) | 21 | 1 |