Subgroups of CLL that express nearly identical Ig heavy and light chains
| IGHV subgroup . | Ig light chain gene . | ||||
|---|---|---|---|---|---|
| IGKV3-20 . | IGKV1-39 . | IGLV3-9 . | IGKV3-11 . | Other VL . | |
| CLL69A (n = 25) | 25* | 0 | 0 | 0 | 0 |
| CLL69B (n = 22) | 0 | 19* | 0 | 0 | 3 |
| CLL69C (n = 13) | 0 | 0 | 10* | 0 | 3 |
| CLL69D (n = 6) | 0 | 0 | 0 | 5* | 1 |
| No HCDR3 motif (n = 192) | 20 | 8 | 2 | 3 | 159 |
| All 51p1 (n = 258) | 45 | 27 | 12 | 8 | 166 |
| CLL (n = 276)† | 27 | 22 | 1 | 12 | 214 |
| IGHV subgroup . | Ig light chain gene . | ||||
|---|---|---|---|---|---|
| IGKV3-20 . | IGKV1-39 . | IGLV3-9 . | IGKV3-11 . | Other VL . | |
| CLL69A (n = 25) | 25* | 0 | 0 | 0 | 0 |
| CLL69B (n = 22) | 0 | 19* | 0 | 0 | 3 |
| CLL69C (n = 13) | 0 | 0 | 10* | 0 | 3 |
| CLL69D (n = 6) | 0 | 0 | 0 | 5* | 1 |
| No HCDR3 motif (n = 192) | 20 | 8 | 2 | 3 | 159 |
| All 51p1 (n = 258) | 45 | 27 | 12 | 8 | 166 |
| CLL (n = 276)† | 27 | 22 | 1 | 12 | 214 |
Values indicate the number of samples within each group of Ig heavy chain samples that expressed an Ig light chain encoded by the IGKV or IGLV gene indicated or by other IGKV or IGLV genes (Other VL).
Indicates a statistically significant difference (P < .001) for the association of the IGKV or IGLV gene expressed by the IGHV subgroup, compared with the expression of that IGKV or IGLV gene with 51p1-encoded Ig heavy chains that do not have that HCDR3 motif, as determined by Fisher exact test with 2-tailed P.
From Stamatopoulos et al.23