CXCL8 production by CBMCs, epithelia, and fibroblasts in response to poly(I:C)
| Cell treatment . | CBMCs . | Skin-derived . | Lung-derived . | ||
|---|---|---|---|---|---|
| Keratinocyte . | HDF . | CCL-204 . | A549 . | ||
| Poly(I:C) 1 (6 h) | 22.1 ± 6.7* | 56.6 ± 23.5 | 2.9 ± 1.2* | 2.0 ± 0.5* | <0.1 ± 0 |
| Poly(I:C) 10 (6 h) | 42.2 ± 12.7* | 73.7 ± 25.9 | 6.0 ± 1.3* | 2.7 ± 0.6† | 0.1 ± 0* |
| Poly(I:C) 1 (24 h) | 257.5 ± 109.2* | 257.9 ± 63.0* | 775.1 ± 359.2 | 5.2 ± 1.9* | <0.1 ± 0.1 |
| Poly(I:C) 10 (24 h) | 735.9 ± 282.9* | 355.8 ± 128.7 | 2221.0 ± 451.3† | 14.8 ± 5.2* | 0.5 ± 0.1* |
| Cell treatment . | CBMCs . | Skin-derived . | Lung-derived . | ||
|---|---|---|---|---|---|
| Keratinocyte . | HDF . | CCL-204 . | A549 . | ||
| Poly(I:C) 1 (6 h) | 22.1 ± 6.7* | 56.6 ± 23.5 | 2.9 ± 1.2* | 2.0 ± 0.5* | <0.1 ± 0 |
| Poly(I:C) 10 (6 h) | 42.2 ± 12.7* | 73.7 ± 25.9 | 6.0 ± 1.3* | 2.7 ± 0.6† | 0.1 ± 0* |
| Poly(I:C) 1 (24 h) | 257.5 ± 109.2* | 257.9 ± 63.0* | 775.1 ± 359.2 | 5.2 ± 1.9* | <0.1 ± 0.1 |
| Poly(I:C) 10 (24 h) | 735.9 ± 282.9* | 355.8 ± 128.7 | 2221.0 ± 451.3† | 14.8 ± 5.2* | 0.5 ± 0.1* |
Data are represented as the mean plus or minus SEM (ng/106 cells) of the increase in CXCL8 production over medium control (n = 3-6) in response to 1 or 10 μg/mL poly(I:C).
Bold numbers denote responses of less than one-fifth of that seen in CBMCs under similar activation conditions.
P < .05, compared with medium control.
P < .01, compared with medium control.