Table 4 Genotype distributions in... | American Society of Hematology

Table 4

Genotype distributions in molecularly distinct subgroups of the CLL cohort

CLL subgroup	No.	Genotype			P vs CLL	P vs counterpart
CLL subgroup	No.	CC, %	GC, %	GG, %	P vs CLL	P vs counterpart
Total cohort	248	62	34	4		.98 (vs control)
IgV mutational status
MUT	149	64	33	3	.73	.24
UM	87	57	37	6	.54	.09
CD38
Less than 30%	143	62	35	2	.65	.27
30% or more	102	61	33	6	.58	.03
ZAP-70
Less than 20%	131	67	29	3	.39	.02
20% or more	59	54	42	3	.28	.01
CD38⁻/ZAP-70⁻	88	67	32	1	.25	.007
CD38⁺/ZAP-70⁺	35	51	46	3	.07	.002
MUT/CD38⁻/ZAP-70⁻	73	68	30	1	.21	<.001
UM/CD38⁺/ZAP-70⁺	25	48	48	4	.01	<.001
Normal/del 13q	161	60	37	3	.87	.14
del 11q/del 17p	43	51	47	2	.04	.12

CLL subgroup	No.	Genotype			P vs CLL	P vs counterpart
CLL subgroup	No.	CC, %	GC, %	GG, %	P vs CLL	P vs counterpart
Total cohort	248	62	34	4		.98 (vs control)
IgV mutational status
MUT	149	64	33	3	.73	.24
UM	87	57	37	6	.54	.09
CD38
Less than 30%	143	62	35	2	.65	.27
30% or more	102	61	33	6	.58	.03
ZAP-70
Less than 20%	131	67	29	3	.39	.02
20% or more	59	54	42	3	.28	.01
CD38⁻/ZAP-70⁻	88	67	32	1	.25	.007
CD38⁺/ZAP-70⁺	35	51	46	3	.07	.002
MUT/CD38⁻/ZAP-70⁻	73	68	30	1	.21	<.001
UM/CD38⁺/ZAP-70⁺	25	48	48	4	.01	<.001
Normal/del 13q	161	60	37	3	.87	.14
del 11q/del 17p	43	51	47	2	.04	.12

Because of rounding, percentages do not always add up to 100.

MUT indicates mutated; UM, unmutated; and del, deletion.