Clinical and molecular characteristics of Richter syndrome patients
| Variable . | Cohort RS, no. (%) . | Collected RS, no. (%) . |
|---|---|---|
| Patients | 16 | 14 |
| Median age at diagnosis, y, n = 16, n = 10* | 64 | 59 |
| Sex (male) | 11 (69) | 10 (71) |
| Binet stage at diagnosis, n = 16, n = 9* | ||
| A | 6 (38) | 3 (33) |
| B | 6 (38) | 3 (33) |
| C | 4 (25) | 3 (33) |
| CD38, n = 14, n = 8* | ||
| 30% or more | 11 (79) | 6 (75) |
| ZAP-70, n = 8, n = 2* | ||
| 20% or more | 1 (12.5) | 1 (50) |
| IgV gene mutation status, n = 16, n = 3* | ||
| UM, less than 2% | 12 (75) | 0 (0) |
| Genomic aberrations, n = 14, n = 3* | ||
| Deletion 11 | 2 (14) | 0 (0) |
| Deletion 17 | 3 (21) | 3 (100) |
| Deletion 13 | 3 (21) | 1 (33) |
| Trisomy 12 | 8 (57) | 0 (0) |
| Normal | 3 (21) | 0 (0) |
| CD38 genotypes, n = 16, n = 14* | ||
| CC | 5 (31) | 5 (36) |
| GC | 9 (56) | 7 (50) |
| GG | 2 (13) | 2 (14) |
| CD38 allele frequencies, n = 16, n = 14* | ||
| C | 0.59 | 0.61 |
| G | 0.41 | 0.39 |
| Variable . | Cohort RS, no. (%) . | Collected RS, no. (%) . |
|---|---|---|
| Patients | 16 | 14 |
| Median age at diagnosis, y, n = 16, n = 10* | 64 | 59 |
| Sex (male) | 11 (69) | 10 (71) |
| Binet stage at diagnosis, n = 16, n = 9* | ||
| A | 6 (38) | 3 (33) |
| B | 6 (38) | 3 (33) |
| C | 4 (25) | 3 (33) |
| CD38, n = 14, n = 8* | ||
| 30% or more | 11 (79) | 6 (75) |
| ZAP-70, n = 8, n = 2* | ||
| 20% or more | 1 (12.5) | 1 (50) |
| IgV gene mutation status, n = 16, n = 3* | ||
| UM, less than 2% | 12 (75) | 0 (0) |
| Genomic aberrations, n = 14, n = 3* | ||
| Deletion 11 | 2 (14) | 0 (0) |
| Deletion 17 | 3 (21) | 3 (100) |
| Deletion 13 | 3 (21) | 1 (33) |
| Trisomy 12 | 8 (57) | 0 (0) |
| Normal | 3 (21) | 0 (0) |
| CD38 genotypes, n = 16, n = 14* | ||
| CC | 5 (31) | 5 (36) |
| GC | 9 (56) | 7 (50) |
| GG | 2 (13) | 2 (14) |
| CD38 allele frequencies, n = 16, n = 14* | ||
| C | 0.59 | 0.61 |
| G | 0.41 | 0.39 |
Percentages refer to total number of events scored.
UM indicates unmutated.
Number of events scored in the collected RS cohort.