Table 1

Effect of sorafenib on cytokine secretion by DCs

CytokineNo sorafenibSorafenib concentration
1 μg/mL3 μg/mL5 μg/mL
IL-12, pg/mL 767 342 40 
IL-10, pg/mL 325 425 88 82 
TNF-α, pg/mL >10 000 >10 000 4633 2824 
IL-6, pg/mL 9758 >10 000 7130 6546 
CytokineNo sorafenibSorafenib concentration
1 μg/mL3 μg/mL5 μg/mL
IL-12, pg/mL 767 342 40 
IL-10, pg/mL 325 425 88 82 
TNF-α, pg/mL >10 000 >10 000 4633 2824 
IL-6, pg/mL 9758 >10 000 7130 6546 

Secretion of IL-12, IL-10, IL-6, and TNF-α was determined in the supernatant of cultured DCs treated with sorafenib and stimulated with LPS using commercially available ELISAs.

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