Table 1 Potential environmental... | American Society of Hematology

Table 1

Potential environmental modifiers of iron loading in hemochromatosis

Modifier	Population studied	Effect	Reference no.
Gastric acid suppression	C282Y homozygotes	Use of proton pump inhibitor reduced venesection requirement	17
Dietary tannins	Volunteer C282Y homozygotes	Regular tea drinking reduced radiolabeled iron absorption. No statistically significant effect on venesection requirement.	18
Dietary iron intake	Female C282Y homozygotes	Positive correlation between heme iron intake and serum ferritin only in postmenopausal women	19
Voluntary blood donation	C282Y homozygotes	No difference in venesection requirements between prior blood donors and nondonors	20
Alcohol consumption	Mouse model	Down-regulates hepcidin expression leading to increased expression of iron transport molecules	21

Modifier	Population studied	Effect	Reference no.
Gastric acid suppression	C282Y homozygotes	Use of proton pump inhibitor reduced venesection requirement	17
Dietary tannins	Volunteer C282Y homozygotes	Regular tea drinking reduced radiolabeled iron absorption. No statistically significant effect on venesection requirement.	18
Dietary iron intake	Female C282Y homozygotes	Positive correlation between heme iron intake and serum ferritin only in postmenopausal women	19
Voluntary blood donation	C282Y homozygotes	No difference in venesection requirements between prior blood donors and nondonors	20
Alcohol consumption	Mouse model	Down-regulates hepcidin expression leading to increased expression of iron transport molecules	21