Genetic factors associated with progression of hepatic fibrosis
| Genetic factor . | Polymorphism . | Study population . | Effect . | Reference no. . |
|---|---|---|---|---|
| Sex | XY | Hemochromatosis | Male sex associated with increased risk of hepatic fibrosis | 7, 9, 12, 54 |
| α1-Antitrypsin | Non MM | Hemochromatosis | No evidence of an increased risk of cirrhosis associated with AAT deficiency | 55 |
| TGFβ1 | Codon 25 Arg/Pro or Pro/Pro | Hemochromatosis | Associated with cirrhosis at a younger age | 56 |
| TNFα | −308 G/A, −238 G/A | Hemochromatosis | No evidence of an association | 56,,–59 |
| Angiotensinogen | −6 G/A | Hemochromatosis | No evidence of an association | 56 |
| GSTP1 | Codon 105 Val/Val | Hemochromatosis | More common in subjects with cirrhosis | 60 |
| MPO | −463G/A | Hemochromatosis | G/G genotype more common in subjects with cirrhosis | 61 |
| MCP-1 | −2518 G/A | Chronic HCV | A/A genotype associated with lower MCP-1 levels, inconsistent associations with fibrosis reported | 62,–64 |
| Genetic factor . | Polymorphism . | Study population . | Effect . | Reference no. . |
|---|---|---|---|---|
| Sex | XY | Hemochromatosis | Male sex associated with increased risk of hepatic fibrosis | 7, 9, 12, 54 |
| α1-Antitrypsin | Non MM | Hemochromatosis | No evidence of an increased risk of cirrhosis associated with AAT deficiency | 55 |
| TGFβ1 | Codon 25 Arg/Pro or Pro/Pro | Hemochromatosis | Associated with cirrhosis at a younger age | 56 |
| TNFα | −308 G/A, −238 G/A | Hemochromatosis | No evidence of an association | 56,,–59 |
| Angiotensinogen | −6 G/A | Hemochromatosis | No evidence of an association | 56 |
| GSTP1 | Codon 105 Val/Val | Hemochromatosis | More common in subjects with cirrhosis | 60 |
| MPO | −463G/A | Hemochromatosis | G/G genotype more common in subjects with cirrhosis | 61 |
| MCP-1 | −2518 G/A | Chronic HCV | A/A genotype associated with lower MCP-1 levels, inconsistent associations with fibrosis reported | 62,–64 |