Quantitation of CXCL1 and CXCL2 in brain and serum of healthy mice
| Ligand*/genotype . | Cxcr2+/+ . | Cxcr2−/− . | Fold change . |
|---|---|---|---|
| CXCL1 | |||
| Brain | 86 ± 19 | 362 ± 200† | 4 |
| Blood | 325 ± 39 | 5691 ± 2000‡ | 17 |
| CXCL2, blood | ND | 464 ± 136 | > 100 |
| Ligand*/genotype . | Cxcr2+/+ . | Cxcr2−/− . | Fold change . |
|---|---|---|---|
| CXCL1 | |||
| Brain | 86 ± 19 | 362 ± 200† | 4 |
| Blood | 325 ± 39 | 5691 ± 2000‡ | 17 |
| CXCL2, blood | ND | 464 ± 136 | > 100 |
Levels of the CXC chemokine, CXCL1 were measured by ELISA in brain supernatants (n = 6 mice per group) and serum (n = 9 mice per group). CXCL2 was measured in serum (n = 4 mice per group).
Data represent the mean ± SD of CXCL1 amount in pg/mg protein. Brain and circulating levels were significantly higher in Cxcr2−/− mice compared with wild-type mice.
P = .008.
P < .001.