Histologic findings of recipient mice
| Group/days . | Liver . | Intestine . | Skin . | ||||||
|---|---|---|---|---|---|---|---|---|---|
| + . | +/− . | − . | + . | +/− . | − . | + . | +/− . | − . | |
| Syngeneic* | |||||||||
| 7 | 0 | 1 | 3 | 0 | 0 | 4 | 0 | 0 | 4 |
| 14 | 0 | 0 | 4 | 0 | 0 | 4 | 0 | 1 | 3 |
| 21 | 0 | 0 | 4 | 0 | 0 | 4 | 0 | 0 | 4 |
| 28 | 0 | 0 | 4 | 0 | 0 | 4 | 0 | 0 | 4 |
| Allogeneic† | |||||||||
| 7 | 5 | 1 | 0 | 4 | 2 | 0 | 4 | 2 | 0 |
| 14 | 6 | 0 | 0 | 6 | 0 | 0 | 5 | 1 | 0 |
| 21 | 6 | 0 | 0 | 6 | 0 | 0 | 6 | 0 | 0 |
| 28 | 4 | 2 | 0 | 5 | 1 | 0 | 5 | 1 | 0 |
| Group/days . | Liver . | Intestine . | Skin . | ||||||
|---|---|---|---|---|---|---|---|---|---|
| + . | +/− . | − . | + . | +/− . | − . | + . | +/− . | − . | |
| Syngeneic* | |||||||||
| 7 | 0 | 1 | 3 | 0 | 0 | 4 | 0 | 0 | 4 |
| 14 | 0 | 0 | 4 | 0 | 0 | 4 | 0 | 1 | 3 |
| 21 | 0 | 0 | 4 | 0 | 0 | 4 | 0 | 0 | 4 |
| 28 | 0 | 0 | 4 | 0 | 0 | 4 | 0 | 0 | 4 |
| Allogeneic† | |||||||||
| 7 | 5 | 1 | 0 | 4 | 2 | 0 | 4 | 2 | 0 |
| 14 | 6 | 0 | 0 | 6 | 0 | 0 | 5 | 1 | 0 |
| 21 | 6 | 0 | 0 | 6 | 0 | 0 | 6 | 0 | 0 |
| 28 | 4 | 2 | 0 | 5 | 1 | 0 | 5 | 1 | 0 |
Formalin-fixed paraffin-embedded sections were stained with hematoxylin and eosin, randomized, and read blindly by an experienced pathologist (Y.K.). Findings, as mentioned in “Histopathologic analysis,” were scored and given an overall interpretation of positive (+), indefinite (+/−), or negative (−) for GVHD.
Days indicates days after bone marrow transplantation; and no., number of mice analyzed.
n = 4.
n = 6.