Personal history of selected autoimmune disorders and pooled relative risk of non-Hodgkin lymphoma (NHL) by autoimmune disease duration
| Disorder* . | Never . | 2-5 years . | 6-10 years . | More than 10 years . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cases . | Controls . | OR (95% CI)† . | Cases . | Controls . | OR (95% CI)† . | Cases . | Controls . | OR (95% CI)† . | Cases . | Controls . | OR (95% CI)† . | |
| Psoriasis | 7460 | 10 122 | 1.00 (referent) | 41 | 40 | 1.35 (0.86-2.10) | 31 | 47 | 0.81 (0.51-1.28) | 200 | 188 | 1.19 (0.97-1.47) |
| Ulcerative colitis | 9775 | 12 148 | 1.00 (referent) | 12 | 19 | 0.83 (0.39-1.75) | 9 | 13 | 0.73 (0.30-0.75) | 86 | 90 | 1.08 (0.80-1.47) |
| Type 1 diabetes | 10 289 | 13 613 | 1.00 (referent) | 1 | 3 | 1.08 (0.11-10.4) | 1 | 3 | 0.66 (0.07-6.55) | 30 | 52 | 0.76 (0.48-1.20) |
| Sarcoidosis | 7607 | 8856 | 1.00 (referent) | 1 | 3 | 0.43 (0.04-4.19) | 1 | 3 | 0.34 (0.03-3.28) | 11 | 15 | 0.78 (0.35-1.71) |
| Pernicious anemia | 3410 | 5865 | 1.00 (referent) | 2 | 2 | 2.10 (0.28-15.6) | 2 | 0 | ND | 4 | 6 | 1.13 (0.31-4.08) |
| Crohn disease | 9230 | 10 614 | 1.00 (referent) | 3 | 4 | 0.92 (0.20-4.25) | 4 | 3 | 1.91 (0.41-8.85) | 12 | 16 | 0.73 (0.34-1.57) |
| Celiac disease | 9343 | 10 424 | 1.00 (referent) | 6 | 5 | 1.30 (0.39-4.28) | 3 | 5 | 0.69 (0.16-2.93) | 20 | 13 | 1.82 (0.89-3.69) |
| Hemolytic anemia | 3242 | 5585 | 1.00 (referent) | 3 | 2 | 2.37 (0.39-14.4) | 2 | 2 | 2.13 (0.29-15.8) | 15 | 9 | 2.50 (1.08-5.83) |
| Systemic lupus erythematosus | 12 034 | 15 237 | 1.00 (referent) | 10 | 1 | 14.6 (1.85-115) | 11 | 6 | 2.46 (0.90-6.75) | 26 | 16 | 1.89 (1.00-3.55) |
| Multiple sclerosis | 9666 | 12 341 | 1.00 (referent) | 1 | 3 | 0.55 (0.06-5.37) | 3 | 0 | ND | 6 | 11 | 0.61 (0.22-1.68) |
| Sjögren syndrome | 8178 | 10 543 | 1.00 (referent) | 15 | 3 | 4.54 (1.31-15.8) | 13 | 1 | 15.7 (2.04-121) | 20 | 4 | 5.07 (1.72-14.9) |
| Primary Sjögren syndrome | 8176 | 10 543 | 1.00 (referent) | 6 | 2 | 2.84 (0.57-14.2) | 2 | 1 | 2.64 (0.23-30.3) | 12 | 2 | 6.37 (1.42-28.6) |
| Secondary Sjögren syndrome | 8178 | 10 542 | 1.00 (referent) | 9 | 1 | 7.92 (1.00-62.8) | 11 | 0 | ND | 8 | 2 | 3.78 (0.79-18.1) |
| Disorder* . | Never . | 2-5 years . | 6-10 years . | More than 10 years . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cases . | Controls . | OR (95% CI)† . | Cases . | Controls . | OR (95% CI)† . | Cases . | Controls . | OR (95% CI)† . | Cases . | Controls . | OR (95% CI)† . | |
| Psoriasis | 7460 | 10 122 | 1.00 (referent) | 41 | 40 | 1.35 (0.86-2.10) | 31 | 47 | 0.81 (0.51-1.28) | 200 | 188 | 1.19 (0.97-1.47) |
| Ulcerative colitis | 9775 | 12 148 | 1.00 (referent) | 12 | 19 | 0.83 (0.39-1.75) | 9 | 13 | 0.73 (0.30-0.75) | 86 | 90 | 1.08 (0.80-1.47) |
| Type 1 diabetes | 10 289 | 13 613 | 1.00 (referent) | 1 | 3 | 1.08 (0.11-10.4) | 1 | 3 | 0.66 (0.07-6.55) | 30 | 52 | 0.76 (0.48-1.20) |
| Sarcoidosis | 7607 | 8856 | 1.00 (referent) | 1 | 3 | 0.43 (0.04-4.19) | 1 | 3 | 0.34 (0.03-3.28) | 11 | 15 | 0.78 (0.35-1.71) |
| Pernicious anemia | 3410 | 5865 | 1.00 (referent) | 2 | 2 | 2.10 (0.28-15.6) | 2 | 0 | ND | 4 | 6 | 1.13 (0.31-4.08) |
| Crohn disease | 9230 | 10 614 | 1.00 (referent) | 3 | 4 | 0.92 (0.20-4.25) | 4 | 3 | 1.91 (0.41-8.85) | 12 | 16 | 0.73 (0.34-1.57) |
| Celiac disease | 9343 | 10 424 | 1.00 (referent) | 6 | 5 | 1.30 (0.39-4.28) | 3 | 5 | 0.69 (0.16-2.93) | 20 | 13 | 1.82 (0.89-3.69) |
| Hemolytic anemia | 3242 | 5585 | 1.00 (referent) | 3 | 2 | 2.37 (0.39-14.4) | 2 | 2 | 2.13 (0.29-15.8) | 15 | 9 | 2.50 (1.08-5.83) |
| Systemic lupus erythematosus | 12 034 | 15 237 | 1.00 (referent) | 10 | 1 | 14.6 (1.85-115) | 11 | 6 | 2.46 (0.90-6.75) | 26 | 16 | 1.89 (1.00-3.55) |
| Multiple sclerosis | 9666 | 12 341 | 1.00 (referent) | 1 | 3 | 0.55 (0.06-5.37) | 3 | 0 | ND | 6 | 11 | 0.61 (0.22-1.68) |
| Sjögren syndrome | 8178 | 10 543 | 1.00 (referent) | 15 | 3 | 4.54 (1.31-15.8) | 13 | 1 | 15.7 (2.04-121) | 20 | 4 | 5.07 (1.72-14.9) |
| Primary Sjögren syndrome | 8176 | 10 543 | 1.00 (referent) | 6 | 2 | 2.84 (0.57-14.2) | 2 | 1 | 2.64 (0.23-30.3) | 12 | 2 | 6.37 (1.42-28.6) |
| Secondary Sjögren syndrome | 8178 | 10 542 | 1.00 (referent) | 9 | 1 | 7.92 (1.00-62.8) | 11 | 0 | ND | 8 | 2 | 3.78 (0.79-18.1) |
ND indicates not determined.
Restricted to a history of the autoimmune disorder with onset at least 2 years before interview/NHL diagnosis. Numbers of participants reporting a particular disease may not add up to the number reporting that disease according to Table 3 because of missing data on disease duration in a few individuals.
Odds ratios (OR) and 95% confidence intervals (CI) computed in a joint-fixed effects model adjusted for age (in 5-year categories), sex, race/ethnicity, education/SES, and study center.