Mortality of compound G-CSF−/−/GM-CSF−/−/IL6−/− mutant mice
| Genotype . | No antibiotics . | With antibiotics . | ||||
|---|---|---|---|---|---|---|
| N . | Percentage dead . | Age at death, d . | N . | Percentage dead . | Age at death, d . | |
| G-CSF−/−/GM-CSF−/−/IL6+/+ | 348 | 0 | NA | 10 | 0 | NA |
| G-CSF−/−/GM-CSF−/−/IL6−/− | 22 | 100 | 4-23 | 242 | 31 | 6-391 |
| Genotype . | No antibiotics . | With antibiotics . | ||||
|---|---|---|---|---|---|---|
| N . | Percentage dead . | Age at death, d . | N . | Percentage dead . | Age at death, d . | |
| G-CSF−/−/GM-CSF−/−/IL6+/+ | 348 | 0 | NA | 10 | 0 | NA |
| G-CSF−/−/GM-CSF−/−/IL6−/− | 22 | 100 | 4-23 | 242 | 31 | 6-391 |
Mice were genotyped as described in ″Animals.″ At weaning, the mice were kept in cages with normal drinking water (no antibiotics) or with water containing 170 mg/L of enrofloxacin. Mice genotyped as wt homozygous for the IL6 gene were routinely kept in cages with normal drinking water.
NA indicates not applicable.