Changes in HIV plasma viral load and lymphocyte subsets during and shortly after CDE chemotherapy (chemo) for entire cohort of 105 patients
| . | Median value at start of chemo (IQR) . | Median change from baseline at 1 mo on chemo (IQR) . | Median change from baseline at 3 mo on chemo (IQR) . | Median change from baseline at end of chemo (IQR) . | Median change from baseline at 1 mo after chemo (IQR) . | Median change from baseline at 3mo after chemo (IQR) . |
|---|---|---|---|---|---|---|
| Subjects, no. | 105 | 97 | 88 | 81 | 73 | 68 |
| CD4 cell count, per mL | 162 (66-269) | −15 (−75-+36); P = .16 | −29 (−95-+33) P = .006 | −41 (−129-+16); P < .001 | −30 (−770-+45); P = .18 | +14 (−59-+72); P = .59 |
| CD8 cell count, per mL | 664 (462-984) | −120 (−367-+71); P < .001 | −294 (−567-+42); P < .001 | −308 (−589-+20); P < .001 | −84 (−422-+142); P = .054 | +88 (−279-+364); P = .64 |
| CD19 cell count, per mL | 86 (47-170) | −63 (−144-−18); P < .001 | −75 (−165-−39); P < .001 | −80 (−168-−42); P < .001 | −69 (−138-−20); P < .001 | −8 (−62-+29); P = .14 |
| CD56 cell count, per mL | 59 (29-116) | −6 (−34-+15) P = .49 | −2 (−44-+22); P = .12 | −10 (−44-+28); P = .059 | +5 (−25-+27); P = .41 | +7 (−22-+29); P = .97 |
| Percentage HIV VL less than 50 copies/mL | 27 | 36 | 57 | 69 | 74 | 79 |
| . | Median value at start of chemo (IQR) . | Median change from baseline at 1 mo on chemo (IQR) . | Median change from baseline at 3 mo on chemo (IQR) . | Median change from baseline at end of chemo (IQR) . | Median change from baseline at 1 mo after chemo (IQR) . | Median change from baseline at 3mo after chemo (IQR) . |
|---|---|---|---|---|---|---|
| Subjects, no. | 105 | 97 | 88 | 81 | 73 | 68 |
| CD4 cell count, per mL | 162 (66-269) | −15 (−75-+36); P = .16 | −29 (−95-+33) P = .006 | −41 (−129-+16); P < .001 | −30 (−770-+45); P = .18 | +14 (−59-+72); P = .59 |
| CD8 cell count, per mL | 664 (462-984) | −120 (−367-+71); P < .001 | −294 (−567-+42); P < .001 | −308 (−589-+20); P < .001 | −84 (−422-+142); P = .054 | +88 (−279-+364); P = .64 |
| CD19 cell count, per mL | 86 (47-170) | −63 (−144-−18); P < .001 | −75 (−165-−39); P < .001 | −80 (−168-−42); P < .001 | −69 (−138-−20); P < .001 | −8 (−62-+29); P = .14 |
| CD56 cell count, per mL | 59 (29-116) | −6 (−34-+15) P = .49 | −2 (−44-+22); P = .12 | −10 (−44-+28); P = .059 | +5 (−25-+27); P = .41 | +7 (−22-+29); P = .97 |
| Percentage HIV VL less than 50 copies/mL | 27 | 36 | 57 | 69 | 74 | 79 |
IQR indicates interquartile range.
All P values were calculated by paired t tests.