Table 1 Clinical and genotypic data on... | American Society of Hematology

Table 1

Clinical and genotypic data on unrelated patients with severe FXI deficiency

	N	No. affected by ischemic stroke	No. affected bymyocardial infarction	FXI genotype
	N	No. affected by ischemic stroke	No. affected bymyocardial infarction	II/II	II/III	III/III	Other	Not tested
Men
45 to 54 y	5	0	0	2	3	0	0	0
55 to 64 y	18	0	4	8	8	1	1*	0
65 to 74 y	13	0	4	7	5	1	0	0
Over 75 y	17	0	6	8	5	4	0	0
Total	53	0	14	25	21	6	1	0
Women
45 to 54 y	17	0	0	5	6	4	1†	1
55 to 64 y	20	0	0	2	15	3	0	0
65 to 74 y	10	0	0	3	4	3	0	0
Over 75 y	15	1	5	5	5	4	1‡	0
Total	62	1	5	15	30	14	2	1
Grand total	115	1	19	40	51	20	3	1

	N	No. affected by ischemic stroke	No. affected bymyocardial infarction	FXI genotype
	N	No. affected by ischemic stroke	No. affected bymyocardial infarction	II/II	II/III	III/III	Other	Not tested
Men
45 to 54 y	5	0	0	2	3	0	0	0
55 to 64 y	18	0	4	8	8	1	1*	0
65 to 74 y	13	0	4	7	5	1	0	0
Over 75 y	17	0	6	8	5	4	0	0
Total	53	0	14	25	21	6	1	0
Women
45 to 54 y	17	0	0	5	6	4	1†	1
55 to 64 y	20	0	0	2	15	3	0	0
65 to 74 y	10	0	0	3	4	3	0	0
Over 75 y	15	1	5	5	5	4	1‡	0
Total	62	1	5	15	30	14	2	1
Grand total	115	1	19	40	51	20	3	1

Type I homozygote,²⁰ FXI level less than 1 U/dL of normal.

Type II/Tyr427Cys compound heterozygote,²¹ FXI level less than 1 U/dL.

Gly555Glu homozygote,²² FXI level less than 1 U/dL.