Table 4 Univariate and multivariate Cox... | American Society of Hematology

Table 4

Univariate and multivariate Cox models for the 4 SNP risk score

No. of deleterious genotypes*	n	Percent dead	Univariate model		Multivariate model†
No. of deleterious genotypes*	n	Percent dead	HR	95% CI	HR	95% CI
0,1	74	12.2	1.00	(reference)	1.00	(reference)
2,3	247	26.7	2.47	1.23-4.96	2.76	1.37-5.56
4	44	47.7	5.63	2.57-12.3	6.77	3.05-15.0
Continuous			1.56	1.26-1.94	1.65	1.32-2.05

No. of deleterious genotypes*	n	Percent dead	Univariate model		Multivariate model†
No. of deleterious genotypes*	n	Percent dead	HR	95% CI	HR	95% CI
0,1	74	12.2	1.00	(reference)	1.00	(reference)
2,3	247	26.7	2.47	1.23-4.96	2.76	1.37-5.56
4	44	47.7	5.63	2.57-12.3	6.77	3.05-15.0
Continuous			1.56	1.26-1.94	1.65	1.32-2.05

P values for trend test are P = 2.8 × 10⁻⁵ and P = 3.7 × 10⁻⁶ for univariate and multivariate models, respectively.

Deleterious genotypes from IL1A (rs1800587), IL8RB (rs1126580), IL4R (rs2107356), and TNF (rs1800629), as coded in Table 2.

Adjusted for age and clinical and demographic factors.