Venous thromboembolism incidence rates and hazard ratios by HDL-c quartile, LITE
| HDL-c quartile, mg/dL . | |||||
|---|---|---|---|---|---|
| Men . | 9.6 to <35.6 . | 35.6 to <43.0 . | 43.0 to <52.0 . | 52.0 to 156 . | |
| Number of events | 44 | 49 | 49 | 55 | |
| Person-years | 24 120 | 27 343 | 27 252 | 26 270 | |
| Incidence rate* | 1.91 | 1.75 | 1.64 | 1.85 | |
| Hazard ratio† | 0.94 | 0.99 | 0.91 | 1.00 | |
| 95% CI | (0.60-1.47) | (0.65-1.51) | (0.60-1.39) | Ref. | |
| Idiopathic VTE | |||||
| Number of events | 12 | 20 | 21 | 22 | |
| Person-years | 23 912 | 27 085 | 27 032 | 26 009 | |
| Hazard ratio† | 0.74 | 1.09 | 1.08 | 1.00 | |
| 95% CI | (0.34-1.62) | (0.55-2.17) | (0.54-2.13) | Ref. | |
| Secondary VTE | |||||
| Number of events | 32 | 29 | 28 | 33 | |
| Person-years | 24 040 | 27 206 | 27 085 | 26 110 | |
| Hazard ratio† | 1.05 | 0.93 | 0.82 | 1.00 | |
| 95% CI | (0.60-1.81) | (0.55-1.59) | (0.48-1.42) | Ref. | |
| HDL-c quartile, mg/dL . | |||||
|---|---|---|---|---|---|
| Men . | 9.6 to <35.6 . | 35.6 to <43.0 . | 43.0 to <52.0 . | 52.0 to 156 . | |
| Number of events | 44 | 49 | 49 | 55 | |
| Person-years | 24 120 | 27 343 | 27 252 | 26 270 | |
| Incidence rate* | 1.91 | 1.75 | 1.64 | 1.85 | |
| Hazard ratio† | 0.94 | 0.99 | 0.91 | 1.00 | |
| 95% CI | (0.60-1.47) | (0.65-1.51) | (0.60-1.39) | Ref. | |
| Idiopathic VTE | |||||
| Number of events | 12 | 20 | 21 | 22 | |
| Person-years | 23 912 | 27 085 | 27 032 | 26 009 | |
| Hazard ratio† | 0.74 | 1.09 | 1.08 | 1.00 | |
| 95% CI | (0.34-1.62) | (0.55-2.17) | (0.54-2.13) | Ref. | |
| Secondary VTE | |||||
| Number of events | 32 | 29 | 28 | 33 | |
| Person-years | 24 040 | 27 206 | 27 085 | 26 110 | |
| Hazard ratio† | 1.05 | 0.93 | 0.82 | 1.00 | |
| 95% CI | (0.60-1.81) | (0.55-1.59) | (0.48-1.42) | Ref. | |
| HDL-c quartile, mg/dL . | |||||
|---|---|---|---|---|---|
| Women . | 11.6 to <46.2 . | 46.2 to <55.9 . | 55.9 to <67.4 . | 67.4 to 163 . | |
| Number of events | 52 | 62 | 71 | 53 | |
| Person-years | 33 414 | 33 568 | 33 559 | 35 461 | |
| Incidence rate* | 1.52 | 1.74 | 1.94 | 1.40 | |
| Hazard ratio† | 0.78 | 0.99 | 1.22 | 1.00 | |
| 95% CI | (0.50-1.20) | (0.66-1.49) | (0.83-1.80) | Ref. | |
| Idiopathic VTE | |||||
| Number of events | 21 | 22 | 32 | 27 | |
| Person-years | 33 107 | 33 211 | 33 205 | 35 270 | |
| Hazard ratio† | 0.54 | 0.70 | 1.08 | 1.00 | |
| 95% CI | (0.27-1.05) | (0.38-1.30) | (0.62-1.88) | Ref. | |
| Secondary VTE | |||||
| Number of events | 31 | 40 | 39 | 26 | |
| Person-years | 33 256 | 33 358 | 33 309 | 35 238 | |
| Hazard ratio† | 1.03 | 1.29 | 1.38 | 1.00 | |
| 95% CI | (0.57-1.85) | (0.74-2.25) | (0.80-2.37) | Ref. | |
| HDL-c quartile, mg/dL . | |||||
|---|---|---|---|---|---|
| Women . | 11.6 to <46.2 . | 46.2 to <55.9 . | 55.9 to <67.4 . | 67.4 to 163 . | |
| Number of events | 52 | 62 | 71 | 53 | |
| Person-years | 33 414 | 33 568 | 33 559 | 35 461 | |
| Incidence rate* | 1.52 | 1.74 | 1.94 | 1.40 | |
| Hazard ratio† | 0.78 | 0.99 | 1.22 | 1.00 | |
| 95% CI | (0.50-1.20) | (0.66-1.49) | (0.83-1.80) | Ref. | |
| Idiopathic VTE | |||||
| Number of events | 21 | 22 | 32 | 27 | |
| Person-years | 33 107 | 33 211 | 33 205 | 35 270 | |
| Hazard ratio† | 0.54 | 0.70 | 1.08 | 1.00 | |
| 95% CI | (0.27-1.05) | (0.38-1.30) | (0.62-1.88) | Ref. | |
| Secondary VTE | |||||
| Number of events | 31 | 40 | 39 | 26 | |
| Person-years | 33 256 | 33 358 | 33 309 | 35 238 | |
| Hazard ratio† | 1.03 | 1.29 | 1.38 | 1.00 | |
| 95% CI | (0.57-1.85) | (0.74-2.25) | (0.80-2.37) | Ref. | |
| HDL-c quartile, mg/dL . | |||||
|---|---|---|---|---|---|
| Men and women . | 9.6 to <40.0 . | 40.0 to <49.1 . | 49.1 to <61.6 . | 61.6 to 163.0 . | |
| Number of events | 108 | 97 | 119 | 111 | |
| Person-years | 56 994 | 58 885 | 62 908 | 62 236 | |
| Incidence rate* | 1.94 | 1.51 | 1.74 | 1.65 | |
| Hazard ratio‡ | 0.92 | 0.77 | 0.94 | 1.00 | |
| 95% CI | (0.67-1.28) | (0.56-1.05) | (0.71-1.26) | Ref. | |
| Idiopathic VTE | |||||
| Number of events | 38 | 39 | 48 | 52 | |
| Person-years | 56 452 | 58 344 | 62 255 | 61 780 | |
| Hazard ratio‡ | 0.73 | 0.67 | 0.88 | 1.00 | |
| 95% CI | (0.43-1.22) | (0.41-1.10) | (0.57-1.36) | Ref. | |
| Secondary VTE | |||||
| Number of events | 70 | 58 | 71 | 59 | |
| Person-years | 56 727 | 58 563 | 62 487 | 61 825 | |
| Hazard ratio‡ | 1.07 | 0.84 | 0.99 | 1.00 | |
| 95% CI | (0.70-1.64) | (0.56-1.27) | (0.67-1.45) | Ref. | |
| HDL-c quartile, mg/dL . | |||||
|---|---|---|---|---|---|
| Men and women . | 9.6 to <40.0 . | 40.0 to <49.1 . | 49.1 to <61.6 . | 61.6 to 163.0 . | |
| Number of events | 108 | 97 | 119 | 111 | |
| Person-years | 56 994 | 58 885 | 62 908 | 62 236 | |
| Incidence rate* | 1.94 | 1.51 | 1.74 | 1.65 | |
| Hazard ratio‡ | 0.92 | 0.77 | 0.94 | 1.00 | |
| 95% CI | (0.67-1.28) | (0.56-1.05) | (0.71-1.26) | Ref. | |
| Idiopathic VTE | |||||
| Number of events | 38 | 39 | 48 | 52 | |
| Person-years | 56 452 | 58 344 | 62 255 | 61 780 | |
| Hazard ratio‡ | 0.73 | 0.67 | 0.88 | 1.00 | |
| 95% CI | (0.43-1.22) | (0.41-1.10) | (0.57-1.36) | Ref. | |
| Secondary VTE | |||||
| Number of events | 70 | 58 | 71 | 59 | |
| Person-years | 56 727 | 58 563 | 62 487 | 61 825 | |
| Hazard ratio‡ | 1.07 | 0.84 | 0.99 | 1.00 | |
| 95% CI | (0.70-1.64) | (0.56-1.27) | (0.67-1.45) | Ref. | |
Ref. indicates reference.
Age-adjusted incidence rate per 1000 person-years.
Multivariable model adjusted for the following covariates at baseline: age, race, study, BMI, diabetes, factor VIIIc, pack-years of smoking, and HRT use in women.
Multivariable model adjusted for the following covariates at baseline: sex, age, race, study, BMI, diabetes, factor VIIIc, pack-years of smoking, and HRT use in women.