Table 4

Treatment-related risk factors for inhibitor development

Risk factorRelative risk95% CI
Age at first infusion < 6 months of age vs > 12 or 18 months 1.828  0.7-4.7 
 1.727  1.3-1.9 
Surgery at first infusion vs treatment of a bleed at first infusion > 5 days of treatment at first infusion vs < 2 days 2.628  1.3-5.1 
 3.328  2.1-5.3 
Prophylaxis vs no prophylaxis 0.428  0.2-0.8 
 0.2*71  0.06-0.5 
Plasma-derived product vs recombinant product 2.427  1.0-5.8 
 0.832  0.5-1.3 
Risk factorRelative risk95% CI
Age at first infusion < 6 months of age vs > 12 or 18 months 1.828  0.7-4.7 
 1.727  1.3-1.9 
Surgery at first infusion vs treatment of a bleed at first infusion > 5 days of treatment at first infusion vs < 2 days 2.628  1.3-5.1 
 3.328  2.1-5.3 
Prophylaxis vs no prophylaxis 0.428  0.2-0.8 
 0.2*71  0.06-0.5 
Plasma-derived product vs recombinant product 2.427  1.0-5.8 
 0.832  0.5-1.3 
*

Odds ratio.

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