Immune-tolerance induction protocols
| Bonn protocol72 . | Malmo protocol63 . | Van Creveld73 . |
|---|---|---|
| fVIII 100 U/kg BID | Immunoadsorption using protein A column if inhibitor titer >10 BU/mL | Factor VIII 25-50 IU/kg |
| FEIBA 100 U/kg BID | BID for 1-2 weeks, then 25 IU/kg every other day | |
| Cyclophosphamide 12-15 mg/kg IV daily × 2 days then 2-3 mg/kg PO daily × 8-10 days | ||
| FVIII is given to achieve a 40%-100% fVIII level followed by fVIII infusion every 8-12 hours to achieve 30%-80% level | ||
| IVIG 2.5-5 g IV immediately after the first fVIII infusion followed by 0.4 g/kg daily days 4-8 |
| Bonn protocol72 . | Malmo protocol63 . | Van Creveld73 . |
|---|---|---|
| fVIII 100 U/kg BID | Immunoadsorption using protein A column if inhibitor titer >10 BU/mL | Factor VIII 25-50 IU/kg |
| FEIBA 100 U/kg BID | BID for 1-2 weeks, then 25 IU/kg every other day | |
| Cyclophosphamide 12-15 mg/kg IV daily × 2 days then 2-3 mg/kg PO daily × 8-10 days | ||
| FVIII is given to achieve a 40%-100% fVIII level followed by fVIII infusion every 8-12 hours to achieve 30%-80% level | ||
| IVIG 2.5-5 g IV immediately after the first fVIII infusion followed by 0.4 g/kg daily days 4-8 |