Results of univariate and multivariate analyses of graft and patient factors influencing neutrophil engraftment
| Variable . | Univariate analysis (includes only significant variables) . | Multivariate analysis (includes only significant variables) . | Favorable in multivariate analysis . | ||||
|---|---|---|---|---|---|---|---|
| Hazard ratio . | 95% CI . | P . | Hazard ratio . | 95% CI . | P . | ||
| Age, y | |||||||
| Older than 2 | 0.52 | 0.36-0.73 | < .01 | 0.59 | 0.42-0.84 | .003 | Patients ≤ 2 y |
| 2 or younger | 1.00 | 1.00 | |||||
| Unit sex | |||||||
| Male | 1.57 | 1.13-2.19 | < .01 | 1.67 | 1.18-2.35 | .003 | Male units |
| Female | 1.00 | 1.00 | |||||
| Cryopreserved cell dose, × 107/kg | |||||||
| More than 9.7 | 1.74 | 1.25-2.43 | < .01 | ||||
| 9.7 or less | 1.00 | ||||||
| Reinfused cell dose, × 107/kg | |||||||
| More than 7.6 | 1.78 | 1.28-2.48 | < .01 | ||||
| 7.6 or less | 1.00 | ||||||
| Reinfused CD34, × 105/kg | |||||||
| More than 2.1 | 1.76 | 1.26-2.46 | < .01 | 1.46 | 1.03-2.08 | .03 | Higher CD34 |
| 2.1 or less | 1.00 | 1.00 | |||||
| Reinfused CFUs, × 104/kg | |||||||
| More than 5.7 | 3.04 | 2.14-4.33 | < .01 | 2.55 | 1.75-3.72 | < .001 | Higher CFUs |
| 5.7 or less | 1.00 | 1.00 | |||||
| Reinfused CD3, × 106/kg | |||||||
| More than 14.2 | 1.63 | 1.16-2.28 | < .01 | ||||
| 14.2 or less | 1.00 | ||||||
| HLA match | |||||||
| 5/6 or 6/6 | 1.44 | 1.02-2.01 | .04 | ||||
| 3/6 or 4/6 | 1.00 | ||||||
| Recipient CMV serostatus | |||||||
| Positive | 0.56 | 0.36-0.86 | < .01 | ||||
| Negative | 1.00 | ||||||
| Variable . | Univariate analysis (includes only significant variables) . | Multivariate analysis (includes only significant variables) . | Favorable in multivariate analysis . | ||||
|---|---|---|---|---|---|---|---|
| Hazard ratio . | 95% CI . | P . | Hazard ratio . | 95% CI . | P . | ||
| Age, y | |||||||
| Older than 2 | 0.52 | 0.36-0.73 | < .01 | 0.59 | 0.42-0.84 | .003 | Patients ≤ 2 y |
| 2 or younger | 1.00 | 1.00 | |||||
| Unit sex | |||||||
| Male | 1.57 | 1.13-2.19 | < .01 | 1.67 | 1.18-2.35 | .003 | Male units |
| Female | 1.00 | 1.00 | |||||
| Cryopreserved cell dose, × 107/kg | |||||||
| More than 9.7 | 1.74 | 1.25-2.43 | < .01 | ||||
| 9.7 or less | 1.00 | ||||||
| Reinfused cell dose, × 107/kg | |||||||
| More than 7.6 | 1.78 | 1.28-2.48 | < .01 | ||||
| 7.6 or less | 1.00 | ||||||
| Reinfused CD34, × 105/kg | |||||||
| More than 2.1 | 1.76 | 1.26-2.46 | < .01 | 1.46 | 1.03-2.08 | .03 | Higher CD34 |
| 2.1 or less | 1.00 | 1.00 | |||||
| Reinfused CFUs, × 104/kg | |||||||
| More than 5.7 | 3.04 | 2.14-4.33 | < .01 | 2.55 | 1.75-3.72 | < .001 | Higher CFUs |
| 5.7 or less | 1.00 | 1.00 | |||||
| Reinfused CD3, × 106/kg | |||||||
| More than 14.2 | 1.63 | 1.16-2.28 | < .01 | ||||
| 14.2 or less | 1.00 | ||||||
| HLA match | |||||||
| 5/6 or 6/6 | 1.44 | 1.02-2.01 | .04 | ||||
| 3/6 or 4/6 | 1.00 | ||||||
| Recipient CMV serostatus | |||||||
| Positive | 0.56 | 0.36-0.86 | < .01 | ||||
| Negative | 1.00 | ||||||
Variables not found to be statistically significant in univariate analysis include performance status (< 80, ≥ 80), recipient sex, unit sex, sex matching (recipient/unit), date of transplantation (after January 1, 2001, before January 1, 2001), recipient ethnicity, unit ethnicity, ethnicity matching (recipient/unit), ABO match, and recipient weight (< 12 kg, ≥ 12 kg).