Distribution of genotypes in childhood ALL patients and controls
| VariantGenotype . | ALL cases, no. (%) . | Controls, no. (%) . | OR (95% CI) . | P . |
|---|---|---|---|---|
| MTHFR 677C>T | ||||
| CC | 130 (53.1) | 219 (44.2) | 1 | |
| CT | 93 (38.0) | 223 (45.0) | 0.7 (0.5-1.0) | .03* |
| TT | 22 (9.0) | 54 (10.9) | 0.7 (0.4-1.2) | .17 |
| CT + TT | 115 (46.9) | 277 (55.8) | 0.7 (0.5-1.0) | .02* |
| MTHFR 1298A>C | ||||
| AA | 110 (44.9) | 229 (47.0) | 1 | |
| AC | 100 (40.8) | 213 (43.7) | 1.0 (0.7-1.4) | .89 |
| CC | 35 (14.3) | 45 (9.2) | 1.6 (1.0-2.7) | .06 |
| AC + CC | 135 (55.1) | 258 (52.9) | 1.1 (0.8-1.5) | .57 |
| MTR 2756A>G | ||||
| AA | 162 (66.1) | 340 (69.5) | 1 | |
| AG | 74 (30.2) | 137 (28.0) | 1.1 (0.8-1.6) | .47 |
| GG | 9 (3.7) | 12 (2.5) | 1.6 (0.7-3.8) | .32 |
| AG + GG | 83 (33.9) | 149 (30.5) | 1.2 (0.8-1.6) | .35 |
| MTRR 66A>G | ||||
| AA | 59 (24.4) | 101 (20.2) | 1 | |
| AG | 117 (48.3) | 245 (49.1) | 0.8 (0.6-1.2) | .31 |
| GG | 66 (27.3) | 153 (30.7) | 0.7 (0.5-1.1) | .17 |
| AG + GG | 183 (75.6) | 397 (79.6) | 0.8 (0.5-1.1) | .20 |
| SHMT 1420C>T | ||||
| CC | 130 (53.3) | 232 (46.7) | 1 | |
| CT | 86 (35.2) | 213 (42.9) | 0.7 (0.5-1.0) | .05 |
| TT | 28 (11.5) | 52 (10.5) | 1.0 (0.6-1.6) | .88 |
| CT + TT | 114 (46.7) | 265 (53.3) | 0.8 (0.6-1.0) | .09 |
| RFC 80G>A | ||||
| GG | 69 (28.6) | 186 (37.6) | 1 | |
| GA | 120 (49.8) | 241 (48.7) | 1.3 (0.9-1.9) | .10 |
| AA | 52 (21.6) | 68 (13.7) | 2.1 (1.3-3.2) | .002* |
| GA + AA | 172 (71.4) | 309 (62.4) | 1.5 (1.1-2.1) | .02* |
| TS 2R3R | ||||
| 3R3R | 80 (32.8) | 123 (25.1) | 1 | |
| 3R2R | 113 (46.3) | 252 (51.3) | 0.7 (0.5-1.0) | .04* |
| 2R2R | 51 (20.9) | 116 (23.6) | 0.7 (0.4-1.0) | .08 |
| 3R2R + 2R2R | 164 (67.2) | 368 (74.9) | 0.7 (0.5-1.0) | .03* |
| NNMT IVS-151C>T | ||||
| CC | 161 (66.0) | 354 (71.2) | 1 | |
| CT | 68 (27.9) | 128 (25.8) | 1.2 (0.8-1.7) | .40 |
| TT | 15 (6.1) | 15 (3.0) | 2.2 (1.1-4.6) | .04* |
| CT + TT | 83 (34.0) | 143 (28.8) | 1.3 (0.9-1.8) | .15 |
| VariantGenotype . | ALL cases, no. (%) . | Controls, no. (%) . | OR (95% CI) . | P . |
|---|---|---|---|---|
| MTHFR 677C>T | ||||
| CC | 130 (53.1) | 219 (44.2) | 1 | |
| CT | 93 (38.0) | 223 (45.0) | 0.7 (0.5-1.0) | .03* |
| TT | 22 (9.0) | 54 (10.9) | 0.7 (0.4-1.2) | .17 |
| CT + TT | 115 (46.9) | 277 (55.8) | 0.7 (0.5-1.0) | .02* |
| MTHFR 1298A>C | ||||
| AA | 110 (44.9) | 229 (47.0) | 1 | |
| AC | 100 (40.8) | 213 (43.7) | 1.0 (0.7-1.4) | .89 |
| CC | 35 (14.3) | 45 (9.2) | 1.6 (1.0-2.7) | .06 |
| AC + CC | 135 (55.1) | 258 (52.9) | 1.1 (0.8-1.5) | .57 |
| MTR 2756A>G | ||||
| AA | 162 (66.1) | 340 (69.5) | 1 | |
| AG | 74 (30.2) | 137 (28.0) | 1.1 (0.8-1.6) | .47 |
| GG | 9 (3.7) | 12 (2.5) | 1.6 (0.7-3.8) | .32 |
| AG + GG | 83 (33.9) | 149 (30.5) | 1.2 (0.8-1.6) | .35 |
| MTRR 66A>G | ||||
| AA | 59 (24.4) | 101 (20.2) | 1 | |
| AG | 117 (48.3) | 245 (49.1) | 0.8 (0.6-1.2) | .31 |
| GG | 66 (27.3) | 153 (30.7) | 0.7 (0.5-1.1) | .17 |
| AG + GG | 183 (75.6) | 397 (79.6) | 0.8 (0.5-1.1) | .20 |
| SHMT 1420C>T | ||||
| CC | 130 (53.3) | 232 (46.7) | 1 | |
| CT | 86 (35.2) | 213 (42.9) | 0.7 (0.5-1.0) | .05 |
| TT | 28 (11.5) | 52 (10.5) | 1.0 (0.6-1.6) | .88 |
| CT + TT | 114 (46.7) | 265 (53.3) | 0.8 (0.6-1.0) | .09 |
| RFC 80G>A | ||||
| GG | 69 (28.6) | 186 (37.6) | 1 | |
| GA | 120 (49.8) | 241 (48.7) | 1.3 (0.9-1.9) | .10 |
| AA | 52 (21.6) | 68 (13.7) | 2.1 (1.3-3.2) | .002* |
| GA + AA | 172 (71.4) | 309 (62.4) | 1.5 (1.1-2.1) | .02* |
| TS 2R3R | ||||
| 3R3R | 80 (32.8) | 123 (25.1) | 1 | |
| 3R2R | 113 (46.3) | 252 (51.3) | 0.7 (0.5-1.0) | .04* |
| 2R2R | 51 (20.9) | 116 (23.6) | 0.7 (0.4-1.0) | .08 |
| 3R2R + 2R2R | 164 (67.2) | 368 (74.9) | 0.7 (0.5-1.0) | .03* |
| NNMT IVS-151C>T | ||||
| CC | 161 (66.0) | 354 (71.2) | 1 | |
| CT | 68 (27.9) | 128 (25.8) | 1.2 (0.8-1.7) | .40 |
| TT | 15 (6.1) | 15 (3.0) | 2.2 (1.1-4.6) | .04* |
| CT + TT | 83 (34.0) | 143 (28.8) | 1.3 (0.9-1.8) | .15 |
OR indicates odds ratio; and CI, confidence interval.
Significant value.