Table 6 Risk groups Risk group .... | American Society of Hematology

Table 6

Risk groups

Risk group	Response			Survival
Risk group	Definition	N (%)	% CR	Definition	N (%)	Median, wk
Age <60
Favorable	No poor prognostic factors*	144 (22)	85	Age ≤ 40 and de novo AML	144 (22)	171
Intermediate	1 poor prognostic factor*	303 (46)	74	Age > 40 or sAML (but not both)	314 (48)	67
Unfavorable	2 or 3 poor prognostic factors*	206 (32)	46	Age > 40 and sAML	195 (30)	46
		P < .001†			P < .001‡
Age ≥60
Favorable	Age < 70 and de novo AML or age < 70, sAML, and WBC ≤ 5000	284 (43)	63	Age < 70 and WBC ≤ 5000	194 (29)	41
Intermediate	Age ≥ 70 and de novo AML or age ≥ 70, sAML, and WBC ≤ 5000	232 (35)	55	Age ≥ 70 or WBC > 5000 (but not both)	331 (50)	33
Unfavorable	sAML and WBC > 5000	148 (22)	37	Age ≥ 70 and WBC > 5000	139 (21)	21
		P < .001†			P < .001‡

Risk group	Response			Survival
Risk group	Definition	N (%)	% CR	Definition	N (%)	Median, wk
Age <60
Favorable	No poor prognostic factors*	144 (22)	85	Age ≤ 40 and de novo AML	144 (22)	171
Intermediate	1 poor prognostic factor*	303 (46)	74	Age > 40 or sAML (but not both)	314 (48)	67
Unfavorable	2 or 3 poor prognostic factors*	206 (32)	46	Age > 40 and sAML	195 (30)	46
		P < .001†			P < .001‡
Age ≥60
Favorable	Age < 70 and de novo AML or age < 70, sAML, and WBC ≤ 5000	284 (43)	63	Age < 70 and WBC ≤ 5000	194 (29)	41
Intermediate	Age ≥ 70 and de novo AML or age ≥ 70, sAML, and WBC ≤ 5000	232 (35)	55	Age ≥ 70 or WBC > 5000 (but not both)	331 (50)	33
Unfavorable	sAML and WBC > 5000	148 (22)	37	Age ≥ 70 and WBC > 5000	139 (21)	21
		P < .001†			P < .001‡

Age > 40, sAML, and sAML with WBC > 8.5/mm³ each count as one poor prognostic factor.

Cochran-Armitage trend test.

From log-logistic model.