Characteristics of HLA-B7+ LRH-1+ patients who received a transplant from an LRH-1− donor
Patient (Pt) . | Diagnosis . | Type of DLI . | Sample date, wk after DLI . | Presence of LRH-1–specific CD8+ T cells . | LRH-1–specific CD8+ T cells (%) in sample . | LRH-1–specific CD8+ T cells (%) after 2 weeks of culture . |
---|---|---|---|---|---|---|
1 | CML | Therapeutic | 25 | + | 1.6 | 12.8 |
2 | CML | Therapeutic | 11 | + | 0.1 | 0.7 |
3 | AML | Preemptive | 10 | + | 6.9 | 15.4 |
4 | AML | Preemptive | 18 | − | < 0.01 | < 0.01 |
5 | B-ALL | Preemptive | 11 | − | < 0.01 | < 0.01 |
6 | T-ALL | Preemptive | 19 | − | < 0.01 | n.d. |
7 | MM | Preemptive | 12 | − | < 0.01 | < 0.01 |
Patient (Pt) . | Diagnosis . | Type of DLI . | Sample date, wk after DLI . | Presence of LRH-1–specific CD8+ T cells . | LRH-1–specific CD8+ T cells (%) in sample . | LRH-1–specific CD8+ T cells (%) after 2 weeks of culture . |
---|---|---|---|---|---|---|
1 | CML | Therapeutic | 25 | + | 1.6 | 12.8 |
2 | CML | Therapeutic | 11 | + | 0.1 | 0.7 |
3 | AML | Preemptive | 10 | + | 6.9 | 15.4 |
4 | AML | Preemptive | 18 | − | < 0.01 | < 0.01 |
5 | B-ALL | Preemptive | 11 | − | < 0.01 | < 0.01 |
6 | T-ALL | Preemptive | 19 | − | < 0.01 | n.d. |
7 | MM | Preemptive | 12 | − | < 0.01 | < 0.01 |
n.d. indicates not determined.